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Chung, Chang, Ohn, Chang, Lee, and Kim: Effect of Botulinum Toxin A for Upper Limb Function in Post Stroke Spastic Hemiplegia
Original Article

Brain & Neurorehabilitation 2010; 3(2): 99-105.

Published online: 30 September 2010

DOI: https://doi.org/10.12786/bn.2010.3.2.99

Effect of Botulinum Toxin A for Upper Limb Function in Post Stroke Spastic Hemiplegia

Chin Wook Chung, M.D., Hyun Jung Chang, M.D.1, Suk Hoon Ohn, M.D.2, Won Hyuk Chang, M.D., Peter K.W. Lee, M.D., Yun-Hee Kim, M.D.

Department of Physical and Rehabilitation Medicine, Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.

1Department of Physical Medicine and Rehabilitation, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Korea.

2Department of Physical Medicine and Rehabilitation, Hallym University College of Medicine, Korea.

Corresponding author (yunkim@skku.edu, yun1225.kim@samsung.com)

Copyright © Korean Society for Neurorehabilitation

Abstract

Objective

Botulinum Toxin A (BoNT-A) is one of the therapeutic methods for the spastic decrement of the upper limb which appears from the patient after stroke. Decrement of stiffness is announced from many studies, but the effect of functional improvement was few examined closely so far clearly. The purpose of this study is to evaluate the effects of BoNT-A for the improvement of upper limb function in post stroke spastic hemiplegia.

Method

Eleven chronic stroke patients (mean age 44.4 years) were included and injected BoNT-A (Dysport®, Ipsen, UK) according to degree of stiffness of each individual. Motor assessment scale, Box and Block test, Peg board test, Ashworth Scale, manual muscle test, Visual analogue scale, and subject satisfaction were applied at the baseline, and 1 week, 1, 2 and 3 months after interventions. All subjects were also submitted to ongoing rehabilitation therapy.

Results

Motor assessment scale results were statistically significant improvements at 1, 2 and 3 months after intervention (p<0.05). Also, statistically significant decreases in muscle tone as determined by the Ashworth scale were found at 1 week, 1, 2 and 3 months after injections (p<0.05).

Conclusion

Botulinum Toxin A could derive the functional improvements as well as the tone reduction of upper limb in post stroke spastic hemiplegia.

Keywords: botulinum Toxin A, stroke, upper limb function

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