Apraxia is a cognitive disorder in which the patient is not able to carry out learned, skilled movement despite preserved motor and sensory system, coordination, comprehension, and cooperation. Several types of apraxia have been postulated according to the involved body part (buccofacial apraxia, limb apraxia) or to the pathophysiology (ideational apraxia, ideomotor apraxia etc.) The main brain lesions for apraxia include left parietal, frontal cortex, their underlying white matter, corpus callosum and some subcortical structures. In this review, the anatomical substrates for apraxia based on underlying physiological mechanism will be discussed.