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Kim: Association of IGF-I Gene Polymorphism with Blood Concentration of IGF-I, Body Composition, Bone Age and Response to Combined Exercise Program in Teen-Aged Children
Clinical Article
The Korean Journal of Sports Medicine

The Korean Journal of Sports Medicine 2012; 30(1): 55-64.

Published online: 4 June 2012

DOI: https://doi.org/10.5763/kjsm.2012.30.1.55

Association of IGF-I Gene Polymorphism with Blood Concentration of IGF-I, Body Composition, Bone Age and Response to Combined Exercise Program in Teen-Aged Children

Kijin Kim, PhD

Department of Physical Education, Keimyung University, Daegu, Korea.

Correspondence: Kijin Kim, PhD. Department of Physical Education, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 704-701, Korea. Tel: +82-53-580-5256, Fax: +82-53-580-5314, kjk744@kmu.ac.kr

Received 5 March 2012       Revised 14 May 2012       Accepted 15 May 2012

Copyright © 2012 The Korean Society of Sports Medicine

Abstract

Association of insulin like growth factor (IGF)-I gene polymorphism with blood concentration of IGF-I, body composition, bone age and response to combined exercise program in teen-aged children. The purpose of this study was to determine whether there are the differences of blood concentration of IGF-I, body composition, bone age and response to combined exercise program according to IGF-I gene polymorphism in Korean teen-aged children. Subjects were recruited by 143 teen-aged children (male: 78, female: 65) from elementary school. Twelve weeks exercise program was consisted of resistance training and aerobic exercise. For the comparison of items and responses to combined exercise program according to IGF-I gene polymorphism, blood concentration of IGF-I, skinfold thickness, body circumferences, and growth markers were measured at baseline and after intervention. Body weight, %fat, BMI, skinfold thickness, circumferences, blood concentration of IGF-I, and bone age showed no significant differences following to IGF-I gene polymorphism. Although body composition and blood concentration of IGF-I showed a positive change after 12 week exercise training, 12 week exercise-mediated changes of body composition and blood concentration of IGF-I showed no significant differences following to IGF-I gene polymorphism. In conclusion, IGF-I gene polymorphism no contributed to the differences of body composition, blood concentration of IGF-I, and 12 week exercise-mediated these changes in teen-aged children.

Keywords: IGF-I gene polymorphism, Children, Growth, Exercise, Body composition

Figures and Tables

Fig. 1
Comparisons of 12 week exercise-mediated changes of body composition according to gender or IGF-I gene polymorphism. *p<0.05, **p<0.01.
kjsm-30-55-g001
Fig. 2
Comparisons of 12 week exercise-mediated changes of body circumferences according to gender or IGF-I gene polymorphism. *p<0.05, **p<0.01, ***p<0.001.
kjsm-30-55-g002
Fig. 3
Comparisons of 12 week exercise-mediated changes of skinfold thickness according to gender or IGF-I gene polymorphism, *p<0.05, **p<0.01, ***p<0.001.
kjsm-30-55-g003
Fig. 4
Comparison of plasma IGF-I level according to gender and IGF-I gene polymorphism.
kjsm-30-55-g004
Fig. 5
Comparison of 12 week exercise-mediated change of plasma IGF-I level according to gender or IGF-I gene polymorphism.
kjsm-30-55-g005
Table 1
Physical characteristic of subject
kjsm-30-55-i001

Values are presented as mean±standard deviation.

Homo: homozygous, Hetero: heterozygous, Non: non-carriers, G: gender, P: polymorphism, LBM: lean body mass, BMI: body mass index, WHR: waist-hip ratio.

*p<0.001 compared to male group; †p<0.001 main effects in group.

Table 2
Twelve week combined exercise training program
kjsm-30-55-i002
Table 3
Comparison of body circumference according to IGF-I polymorphism and gender
kjsm-30-55-i003

Values are presented as mean±standard deviation.

IGF-I: insulin like growth factor, Homo: homozygous, Hetero: heterozygous, Non: non-carriers, G: gender, P: polymorphism.

*p<0.01 main effects in group; †p<0.05, ‡p<0.001 compared to male group.

Table 4
Comparison of skinfold thickness according to IGF-I polymorphism and gender
kjsm-30-55-i004

Values are presented as mean±standard deviation.

IGF-I: insulin like growth factor, Homo: homozygous, Hetero: heterozygous, Non: non-carriers, G: gender, P: polymorphism.

Table 5
Comparison of growth factor according to IGF-I polymorphism and gender
kjsm-30-55-i005

Values are presented as mean±standard deviation.

IGF-I: insulin like growth factor, Homo: homozygous, Hetero: heterozygous, Non: non-carriers, G: gender, P: polymorphism.

*p<0.001 compared to male group; †p<0.01 main effects in group.

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