Journal List > J Korean Soc Menopause > v.19(2) > 1052107

Lee, Ok, Kim, and Cho: A Clinical Analysis of Patients with Premature Ovarian Failure: Compliance with Hormonal Treatment



To analyze the clinical features of premature ovarian failure (POF) and patients' compliance with hormonal treatment.


A retrospective analysis of 126 patients diagnosed with POF was selected between January 2004 and December 2007. The clinical, etiologic features and treatment compliance were evaluated.


The mean age of diagnosis was 33.2 ± 5.2 years. The mean value of follicle stimulating hormone was 78.8 ± 28.8 IU/L. The most common symptom was amenorrhea or oligomenorrhea (54%). Eighty-eight patients were married and 22 of them visited our clinic due to infertility. The most common etiology was unknown (54.8%) and the second most common cause was iatrogenic (29.4%). Only 61 patients underwent hormonal treatment (48.4%). The remaining 11 patients did not undergo hormonal treatment due to other medical conditions such as breast cancer or liver disease; however, they were followed-up regularly (8.7%). Among the treatment group, only 37 patients were followed-up over a period of 12 months (60.7%).


About half of the women diagnosed with POF did not accept their own problems and therefore delayed essential treatment. Clinicians should educate the importance of early treatment for preventing degenerative changes.

Figures and Tables

Table 1
Patients' characteristics (n = 126)

*Three patients had primary amenorrhea.

BMI: body mass index, FSH: follicle stimulating hormone

Table 2
Etiology of premature ovarian failure
Table 3
Patients' compliance with hormonal treatment

IVF: in vitro fertilization

Table 4
Age group and hormonal treatment
Table 5
Etiology and hormonal treatment


This work is supported by the Dong-A University research fund.


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