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Lee, Ok, Kim, and Cho: A Clinical Analysis of Patients with Premature Ovarian Failure: Compliance with Hormonal Treatment
Original Article

The Journal of Korean Society of Menopause 2013; 19(2): 87-92.

Published online: 27 August 2013

DOI: https://doi.org/10.6118/jksm.2013.19.2.87

A Clinical Analysis of Patients with Premature Ovarian Failure: Compliance with Hormonal Treatment

Hee Suk Lee, M.D.1, Ji Hoon Ok, M.D.1, Joo Myung Kim, M.D., Ph.D.2, Yeon Jean Cho, M.D., Ph.D.1

1Department of Obstetrics and Gynecology, Dong-A University Medical Center, Dong-A University, College of Medicine, Busan, Korea.

2Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.

Address for Correspondence: Yeon Jean Cho, Department of Obstetrics and Gynecology, Dong-A University School of Medicine, Dongdaeshin-dong 3 ga-1, Seo-gu, Busan 602-715, Korea. Tel: +82-51-240-5090, Fax: +82-51-244-9553, jeanjane@naver.com

Received 9 June 2013       Revised 10 July 2013       Accepted 23 July 2013

Copyright © 2013 by The Korean Society of Menopause

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Objectives

To analyze the clinical features of premature ovarian failure (POF) and patients' compliance with hormonal treatment.

Methods

A retrospective analysis of 126 patients diagnosed with POF was selected between January 2004 and December 2007. The clinical, etiologic features and treatment compliance were evaluated.

Results

The mean age of diagnosis was 33.2 ± 5.2 years. The mean value of follicle stimulating hormone was 78.8 ± 28.8 IU/L. The most common symptom was amenorrhea or oligomenorrhea (54%). Eighty-eight patients were married and 22 of them visited our clinic due to infertility. The most common etiology was unknown (54.8%) and the second most common cause was iatrogenic (29.4%). Only 61 patients underwent hormonal treatment (48.4%). The remaining 11 patients did not undergo hormonal treatment due to other medical conditions such as breast cancer or liver disease; however, they were followed-up regularly (8.7%). Among the treatment group, only 37 patients were followed-up over a period of 12 months (60.7%).

Conclusion

About half of the women diagnosed with POF did not accept their own problems and therefore delayed essential treatment. Clinicians should educate the importance of early treatment for preventing degenerative changes.

Keywords: Compliance, Hormone replacement therpay, Premature ovarian failure, Primary ovarian insufficiency

Figures and Tables

Table 1
Patients' characteristics (n = 126)
jksm-19-87-i001

*Three patients had primary amenorrhea.

BMI: body mass index, FSH: follicle stimulating hormone

Table 2
Etiology of premature ovarian failure
jksm-19-87-i002
Table 3
Patients' compliance with hormonal treatment
jksm-19-87-i003

IVF: in vitro fertilization

Table 4
Age group and hormonal treatment
jksm-19-87-i004
Table 5
Etiology and hormonal treatment
jksm-19-87-i005

Notes

This work is supported by the Dong-A University research fund.

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