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Kim, Lee, Lee, Oh, Hong, Choi, Jae, Lee, and Kim: Association between Serum Homocysteine Concentrations and Bone Mineral Density in Middle Aged Women
Original Article

The Journal of Korean Society of Menopause 2013; 19(2): 81-86.

Published online: 27 August 2013

DOI: https://doi.org/10.6118/jksm.2013.19.2.81

Association between Serum Homocysteine Concentrations and Bone Mineral Density in Middle Aged Women

Ari Kim, M.D.1, Jun Hee Lee, M.D.1, Ji Young Lee, M.D.2, Young Min Oh, M.D.3, Sung-Nam Hong, M.D.4, Hoon Choi, M.D.5, Eun-Ae Jae, M.D.3, Hae-Hyeog Lee, M.D.6, Heung Yeol Kim, M.D.3

1Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea.

2Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.

3Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea.

4Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

5Department of Obstetrics and Gynecology, College of Medicine, Inje University, Seoul, Korea.

6Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Address for Correspondence: Heung Yeol Kim, Department of Obstetrics and Gynecology, College of Medicine, Kosin University, 31, Amnam-dong, Seo-gu, Busan 607-702, Korea. Tel: +82-51-990-6226, Fax: +82-51-990-3300, hykyale@yahoo.com

Address for Correspondence: Young Min Oh, Department of Obstetrics and Gynecology, College of Medicine, Kosin University, 31, Amnam-dong, Seo-gu, Busan 607-702, Korea. Tel: +82-51-990-6114, Fax: +82-51-990-3300, 5788421@hanmail.net

Received 28 March 2013       Revised 22 April 2013       Accepted 22 April 2013

Copyright © 2013 by The Korean Society of Menopause

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Objectives

Hyperhomocysteinemia is known to be related with the early onset of osteoporosis. This study was to examine the association between serem homocysteine levels and bone mineral density (BMD) in middle aged women.

Methods

The study included 409 women who underwent bone density tests in the health screening centers from January 2009 to october 2010. Serum homocysteine levels and BMD were measured.

Results

Postmenopause group (n = 109) showed significantly lower BMD score in lumbar spine and femoral neck and significantly higher serum homocysteine concentration compared to premenopause group (n = 300). However, after adjusting for age, body mass index, and the menopausal condition in total 409 women, there were no significant correlations between serum homocysteine levels and BMD.

Conclusion

Measurement of serum homocysteine levels may not be useful, but adjunctive for the risk assessment of osteoporosis in middle aged women.

Keywords: Bone density, Homocysteine, Osteoporosis

Figures and Tables

Table 1
Clinical characteristics of the subjects distributed by menopausal status
jksm-19-81-i001

*Unpaired t-test was performed to determine the differences in clinical characteristics between premenopausal and postmenopausal women.

BMI: body mass index, BMD: bone mineral density

Table 2
Multiple linear regression analysis on bone mineral density (g/cm2) in total premenopausal and postmenopausal women (n = 409)
jksm-19-81-i002

BMD: bone mineral density, BMI: body mass index

Table 3
Multiple linear regression analysis on bone mineral density (g/cm2) in premenopausal women (n = 300)
jksm-19-81-i003

BMD: bone mineral density, BMI: body mass index

Table 4
Multiple linear regression analysis on bone mineral density (g/cm2) in postmenopausal women (n = 109)
jksm-19-81-i004

BMD: bone mineral density, BMI: body mass index

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