Journal List > J Korean Soc Menopause > v.18(3) > 1052078

Joo, Son, Jung, Kim, and Lee: Differences of Prevalence and Components of Metabolic Syndrome according to Menopausal Status

Abstract

Objectives

Metabolic and endocrinologic alterations is developed at menopausal transition of women and these alterations can have an effect on prevalence of metabolic syndrome. Therefore, we evaluated the prevalence of metabolic syndrome and differences of components as menopausal status of women who visited our health screening clinic.

Methods

We surveyed body sizes, blood pressures and other several blood tests from January 2006 to December 2010 in Pusan National University Hospital by retrospectively reviewing medical records. These results were compared as presence of metabolic syndrome and menopausal status. Differences of the components of metabolic syndrome as the menopausal status and occurrences of metabolic syndrome as the age and the menopausal status are investigated.

Results

In premenopausal and postmenopausal women, the prevalence of metabolic syndrome were 8.69% and 21.85%, respectively. More body weight, high body mass index and cholesterol were checked in women who have metabolic syndrome irrespective of menopausal status. Low high density lipoprotein was most prominent component of metabolic syndrome irrespective of menopausal status. Hypertension and high blood sugar were showed meaningful proportions in postmenopausal women. The prevalence of metabolic syndrome was unrelated to the menopausal status by regressively analyze, but meaningfully increased related to aging.

Conclusion

Menopausal alterations restrictively effect on occurrence of metabolic syndrome and aging is more effect on it. But more detailed and additional studies are needed about determining the relation of metabolic syndrome in women who surgically menopaused and receiving hormone therapy.

Figures and Tables

Table 1
Clinical characteristics of the subjects
jksm-18-155-i001

Data are presented as the means ± SD.

SBP: systolic blood pressure, DBP: diastolic blood pressure, WC: waist circumference, BMI: body mass index, TC: total cholesterol, TG: triglyceride, HDL: high density lipoprotein, LDL: low density lipoprotein, FFA: free fatty acid, FT4: free thyroxine, TSH: thyroid stimulating hormone, HOMA-IR: homeostasis model of assessment-insulin resistance.

P value by student t-test. *P value < 0.05

Table 2
Differences of clinical factor according to presence of metabolic syndrome in premenopausal women
jksm-18-155-i002

Data are presented as the means ± SD.

SBP: systolic blood pressure, DBP: diastolic blood pressure, WC: waist circumference, BMI: body mass index, TC: total cholesterol, TG: triglyceride, HDL: high density lipoprotein, LDL: low density lipoprotein, FFA: free fatty acid, FT4: free thyroxine, TSH: thyroid stimulating hormone, HOMA-IR: homeostasis model of assessment-insulin resistance.

P value by student t-test. *between premenopausal groups, between postmenopausal groups, between metabolic syndrome groups

Table 3
Prevalence of metabolic syndrome components according to menopausal status
jksm-18-155-i003

HDL: high density lipoprotein.

P value by student t-test. *P value < 0.05

Table 4
Prevalence of metabolic syndrome according to the National Cholesterol Education Program by menopausal status and age group
jksm-18-155-i004

MS: metabolic syndrome, OR: odds ratio, CI: confidence interval

P value by logistic regression. *P value < 0.05

References

1. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002. 288:1723–1727.
2. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003. 348:1625–1638.
3. Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab. 2004. 89:2583–2589.
4. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002. 287:356–359.
5. von Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E. Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int. 2007. 18:1337–1344.
6. Najarian RM, Sullivan LM, Kannel WB, Wilson PW, D'Agostino RB, Wolf PA. Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: the Framingham Offspring Study. Arch Intern Med. 2006. 166:106–111.
7. Lovejoy JC. The menopause and obesity. Prim Care. 2003. 30:317–325.
8. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003. 88:2404–2411.
9. National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002. 106:3143–3421.
10. Li Z, McNamara JR, Fruchart JC, Luc G, Bard JM, Ordovas JM, et al. Effects of gender and menopausal status on plasma lipoprotein subspecies and particle sizes. J Lipid Res. 1996. 37:1886–1896.
11. Lindheim SR, Buchanan TA, Duffy DM, Vijod MA, Kojima T, Stanczyk FZ, et al. Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J Soc Gynecol Investig. 1994. 1:150–154.
12. Jeon SK, Hong HR, Yi KW, Park HT, Shin JH, Lee NW, et al. Relationship between metabolic syndrome and bone mineral density in middle-aged women. J Korean Soc Menopause. 2010. 16:142–147.
13. Kim HM, Park J, Ryu SY, Kim J. The effect of menopause on the metabolic syndrome among Korean women: the Korean National Health and Nutrition Examination Survey, 2001. Diabetes Care. 2007. 30:701–706.
14. Cho GJ, Park HT, Shin JH, Kim T, Hur JY, Kim YT, et al. The relationship between reproductive factors and metabolic syndrome in Korean postmenopausal women: Korea National Health and Nutrition Survey 2005. Menopause. 2009. 16:998–1003.
15. Roos A, Bakker SJ, Links TP, Gans RO, Wolffenbuttel BH. Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects. J Clin Endocrinol Metab. 2007. 92:491–496.
16. Royer M, Castelo-Branco C, Blümel JE, Chedraui PA, Danckers L, Bencosme A, et al. The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III): prevalence of the metabolic syndrome in postmenopausal Latin American women. Climacteric. 2007. 10:164–170.
17. Deibert P, König D, Vitolins MZ, Landmann U, Frey I, Zahradnik HP, et al. Effect of a weight loss intervention on anthropometric measures and metabolic risk factors in pre-versus postmenopausal women. Nutr J. 2007. 6:31.
18. Duntas LH. Thyroid disease and lipids. Thyroid. 2002. 12:287–293.
19. Figueiredo Neto JA, Figuerêdo ED, Barbosa JB, Barbosa Fde F, Costa GR, Nina VJ, et al. Metabolic syndrome and menopause: cross-sectional study in gynecology clinic. Arq Bras Cardiol. 2010. 95:339–345.
20. Oh JY, Hong YS, Sung YA, Barrett-Connor E. Prevalence and factor analysis of metabolic syndrome in an urban Korean population. Diabetes Care. 2004. 27:2027–2032.
21. Novgorodtseva TP, Karaman YK, Zhukova NV, Lobanova EG, Antonyuk MV, Kantur TA. Composition of fatty acids in plasma and erythrocytes and eicosanoids level in patients with metabolic syndrome. Lipids Health Dis. 2011. 10:82.
22. Pandey S, Srinivas M, Agashe S, Joshi J, Galvankar P, Prakasam CP, et al. Menopause and metabolic syndrome: A study of 498 urban women from western India. J Midlife Health. 2010. 1:63–69.
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