Journal List > J Korean Soc Menopause > v.17(3) > 1052066

Cho: Serum Ferritin and Metabolic Syndrome in Perimenopausal and Postmenopausal Women

Abstract

Objectives

The purpose of this study was to examine the relationship between serum ferritin and metabolic syndrome in peri- and postmenopausal women.

Methods

The study subjects consisted of 2,091 peri- and postmenopausal women who visited the hospital for a health check-up in 2007. They were divided into the metabolic syndrome group (MetS) and the non-metabolic syndrome group (Non-MetS).

Results

Mean serum ferritin values were 65.16 ± 33.69 ng/mL in MetS and 57.82 ± 32.51 ng/mL in Non-MetS (P = 0.000). In MetS, serum ferritin had a positive correlation with hemoglobin (Hb), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, aspartate transaminase (SGOT), alanine transaminase (SGPT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) but a negative correlation with high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol (P < 0.05). From multiple linear models, hs-CRP, HDL-cholesterol, SGOT, HOMA-IR, and hemoglobin level were found to be the best predictors of serum ferritin in MetS (R2 = 0.106; P < 0.05).

Conclusion

The serum ferritin level in MetS was higher than in Non-MetS in postmenopausal women. In MetS, with increasing hs-CRP, SGOT, HOMA-IR, and hemoglobin levels and decreasing HDL-cholesterol levels, the serum ferritin level seems to increase

Figures and Tables

Table 1
Comparison of baseline characteristics between metabolic syndrome and non-metabolic syndrome
jksm-17-166-i001

HbA1c: hemoglobin A1c, Values given are number of patients (%) or mean ± SD. HOMA-IR: homeostasis model assessment insulin resistance, HDL: high-density lipoprotein, LDL: low-density lipoprotein, SGOT: aspartate transaminase, SGPT: alanine transaminase, γGTP: γ-glutamyl transpeptidase, hs-CRP: high-sensitivity C-reactive protein. T-test (continuous variables): *P value using chi-square test (categorical variables).

Table 2
Correlations between serum ferritin§ and various parameters in total, metabolic syndrome and non-metabolic syndrome
jksm-17-166-i002

HbA1c: hemoglobin A1c, HOMA-IR: homeostasis model assessment insulin resistance, HDL: high-density lipoprotein, LDL: low-density lipoprotein, SGOT: aspartate transaminase, SGPT: alanine transaminase, γGTP: γ-glutamyl transpeptidase, hs-CRP: high-sensitivity C-reactive protein. Pearson correlation coefficient: *spearman's correlation coefficient; P < 0.05; P < 0.01. §Log-transformed values were used for analysis.

Table 3
Associations of serum ferritin with various parameters by multiple linear regression analysis
jksm-17-166-i003

R2 = 0.078. SE: standard error, HDL: high-density lipoprotein, hs-CRP: high-sensitivity C-reactive protein, γGTP: γ-glutamyl transpeptidase, SGOT: aspartate transaminase

Table 4
Associations of serum ferritin with various parameters in metabolic syndrome by multiple linear regression analysis
jksm-17-166-i004

R2 = 0.106. SE: standard error, hs-CRP: high-sensitivity C-reactive protein, LDL: low-density lipoprotein, SGOT: aspartate transaminase, HOMA-IR: homeostasis model assessment insulin resistance

Table 5
Associations of serum ferritin with various parameters in non-metabolic syndrome by multiple linear regression analysis
jksm-17-166-i005

R2 = 0.070. SE: standard error, HDL: high-density lipoprotein, γGTP: γ-glutamyl transpeptidase

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