Journal List > J Korean Soc Menopause > v.17(3) > 1052065

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Huh, Seo, Kim, Chung, Yoon, Lee, Kang, Choi, Park, Kim, and The Study Group of Menopause: Retrospective Multicenter Study on Clinical Aspects in Premature Ovarian Failure
Original Article
The Journal of Korean Society of Menopause

The Journal of Korean Society of Menopause 2011; 17(3): 160-165.

Published online: 31 December 2011

DOI: https://doi.org/10.6118/jksm.2011.17.3.160

Retrospective Multicenter Study on Clinical Aspects in Premature Ovarian Failure

Ji Su Huh, M.D.1, Seok Kyo Seo, M.D.1, Mee-Ran Kim, M.D.2, Hye Won Chung, M.D.3, Byung-Koo Yoon, M.D.4, Byung Seok Lee, M.D.1, Byung Moon Kang, M.D.5, Hoon Choi, M.D.6, Hyung Moo Park, M.D.7, Jung Gu Kim, M.D.8; The Study Group of Menopause

1Department of Obstetrics and Gynecology, College of Medicine, Yonsei University, Seoul, Korea.

2Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

3Department of Obstetrics and Gynecology, College of Medicine, Ewha Woman's University, Seoul, Korea.

4Department of Obstetrics and Gynecology, College of Medicine, Sungkyunkwan University, Seoul, Korea.

5Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Seoul, Korea.

6Department of Obstetrics and Gynecology, College of Medicine, Inje University, Seoul, Korea.

7Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University, Seoul, Korea.

8Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.

Corresponding author (dr222@yuhs.ac)

Received 27 July 2011       Accepted 10 October 2011

Copyright © 2011 by The Korean Society of Menopause

Abstract

Objectives

Premature ovarian failure (POF) is a syndrome defined as the cessation of ovarian function before the age of 40 years that is characterized by amenorrhoea associated with elevated gonadotropin levels. The aim of this study was to compare clinical manifestation of primary amenorrhea and secondary amenorrhea group.

Methods

This study was designed as a retrospective multicenter study of 262 women with premature ovarian failure. Sixty eight women with primary amenorrhea and 194 women with secondary amenorrhea were evaluated and hormonal level, lipid profile, bone mineral density, and pregnancy rates were compared.

Results

The estradiol level was markedly lower in primary amenorrhea than secondary amenorrhea. The pregnancy rate of 43.3% before the diagnosis in secondary amenorrhea was markedly higher than the rate of 0% in primary amenorrhea. The pregnancy rates after treatment was 5.9% in primary amenorrhea, but 1.0% after diagnosis and 2.8% after treatment in secondary amenorrhea. The pregnancy rate after hormonal treatment was 3.7% in total, 8.3% in primary amenorrhea, and 2.8% in secondary amenorrhea. In nine cases of pregnancy, seven cases were after estrogen-progestin (EP), one case was after clomiphene citrate and one case was after EP/human menopausal gonodotropin (hMG). And In nine cases of pregnancy, six cases resulted from oocyte donation. The prevalence of osteopenia/osteoporosis was markedly higher in primary amenorrhea than in secondary amenorrhea.

Conclusion

Premature ovarian failure has negative influences on the physical and psychological health of young patients. Effective management should include earlier diagnosis and intensive medical intervention to relieve symptoms of estrogen deficiency and to treat long-term disease such as osteoporosis and in assisted pregnancy by oocyte donation.

Keywords: Premature ovarian failure, Primary amenorrhea, Secondary amenorrhea

Figures and Tables

Table 1
Comparison of age, body weight and hormone level between primary and secondary amenorrhea
jksm-17-160-i001

Calculated by student's t-test, BMI: body mass index, FSH: follicle stimulating hormone, E2: estradiol, LH: luteinizing hormone

Table 2
Comparison of lipid profile and thyroid hormone level between primary and secondary amenorrhea
jksm-17-160-i002

Calculated by student's t-test. T3: triiodothyronine, fT4: free thyroxine

Table 3
Reproductive performance in primary and secondary amenorrhea
jksm-17-160-i003
Table 4
Pregnancy rates by ovulation induction in primary and secondary amenorrhea
jksm-17-160-i004

hMG: human menopausal gonadotropin

Table 5
Predictability of pregnancy by endocrinologic findings in premature ovarian failure patients
jksm-17-160-i005

Calculated by Chi-square (Fisher's exact test). LH: luteinizing hormone, FSH: follicle stimulating hormone, E2: estradiol

Table 6
Comparison of bone mineral density between in primary and secondary amenorrhea
jksm-17-160-i006

Calculated by student's t-test

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