Rosai-Dorfman Disease as a Solitary Lesion of the Tibia

Chang-Bae Kong; Jung-Wook Lee; Sang-Hyun Cho; Won-Seok Song; Wan-Hyeong Cho; Jae-Soo Koh; Dae-Geun Jeon; Soo-Yong Lee

doi:10.5292/jkbjts.2014.20.1.32

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Kong, Lee, Cho, Song, Cho, Koh, Jeon, and Lee: Rosai-Dorfman Disease as a Solitary Lesion of the Tibia

Case Report

J Korean Bone Joint Tumor Soc 2014;20(1):32-35.

Published online: 10 June 2014

DOI: https://doi.org/10.5292/jkbjts.2014.20.1.32

Rosai-Dorfman Disease as a Solitary Lesion of the Tibia

Chang-Bae Kong, Jung-Wook Lee, Sang-Hyun Cho, Won-Seok Song, Wan-Hyeong Cho, Jae-Soo Koh^*, Dae-Geun Jeon, Soo-Yong Lee

Department of Orthopedic Surgery, Seoul, Korea

^*Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea

Correspondence to: Wan-Hyeong Cho Department of Orthopedic Surgery, Korea Cancer Center Hospital, 75, Nowon-ro, Nowon-gu, Seoul 139-706, Korea TEL: +82-2-970-1243 FAX: +82-2-970-2403 E-mail: chowanda@naver.com

Received 14 March 2014 Revised 26 May 2014 Accepted 3 June 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rosai-Dorfman disease (RDD) is an idiopathic histioproliferative disorder of lymph node and extranodal site. Bone involvement is very rare. We report a case of extranodal RDD of the tibia in 32-year old male. The patient presented with pain with no evidence of lymphadenopathy. Clinico-radiologic diagnosis was metastatic carcinoma or Langerhans cell histiocytosis, but, histopathologic examination confirmed the diagnosis with RDD. We performed curettage on the osteolytic lesion of tibia. In South Korea, there was no report about RDD of the extremity and we want to report this case with review of the literature.

Keywords: Rosai-dorfman disease, bone, tibia

References

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Figure 1.

Anteroposterior view (A) & lateral view (B) of plain radiographs of left tibia show osteolytic bony lesion with endosteal scalloping.

Figure 2.

(A) Sagittal T1-weigthed MR image of lower leg shows bony lesion with low signal intensity. (B) Coronal T2-weighted MR image shows bony lesion with low to intermediate signal intensity.

Figure 3.

Preoperative bone scan shows increased uptake of left tibia mid-shaft. There is no abnormal uptake except left tibia.

Figure 4.

(A) H&E staining shows large, pale histiocytes with emperiopolesis (×200). (B) Immunohistochemistry staining shows that these histiocytes are positive for S-100 protein (×200).

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