Tumor Lysis Syndrome Induced by Radiotherapy in Non-Small Cell Lung Cancer

Dong-Hyo Noh; Ki-Eun Hwang; Jeong-Hyun Shin; Dong Kim; Kyung-Hwa Cho; Keum-Ha Choi; Seong-Hoon Park; Eun-Taik Jeong; Hak-Ryul Kim

doi:10.6058/jlc.2010.9.2.106

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Noh, Hwang, Shin, Kim, Cho, Choi, Park, Jeong, and Kim: Tumor Lysis Syndrome Induced by Radiotherapy in Non-Small Cell Lung Cancer

Original Article

J Lung Cancer 2010;9(2):106-109.

Published online: 10 January 2010

DOI: https://doi.org/10.6058/jlc.2010.9.2.106

Tumor Lysis Syndrome Induced by Radiotherapy in Non-Small Cell Lung Cancer

Dong-Hyo Noh, M.D.¹, Ki-Eun Hwang, M.D.¹, Jeong-Hyun Shin, M.D.¹, Dong Kim, M.D.¹, Kyung-Hwa Cho, M.D.¹, Keum-Ha Choi, M.D.², Seong-Hoon Park, M.D.³, Eun-Taik Jeong, M.D.¹, Hak-Ryul Kim, M.D.¹

¹Departments of Internal Medicine

²Pathology

³Radiology, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea

Address for correspondence Hak-Ryul Kim, M.D. Department of Internal Medicine, Wonkwang University School of Medicine, 344-2, Shinyong-dong, Iksan 570-749, Korea Tel: 82-63-859-2583 Fax: 82-63-855-2025 E-mail: kshryj@wonkwang.ac.kr

This study was supported by grant from Wonkwang University in 2009.

Received 14 July 2010 Revised 14 September 2010 Accepted 27 September 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tumor lysis syndrome (TLS) is an oncologic emergency that is characterized by numerous metabolic abnormalities, including hyperuricemic nephropathy, hyperphosphatemia, hypocalcemia, hyperkalemia and increased serum creatinine. This syndrome is common for tumors with rapid cell turnover and growth rates, and for bulky tumors with high sensitivity to anti-neoplastic treatments. Hence, TLS is a well-recognized clinical problem in hematologic malignancies. TLS is rarely observed to be induced in solid tumors by chemotherapy. Herein we present the second case of TLS that developed during radiotherapy in a patient with non-small cell lung cancer.

Keywords: Tumor lysis syndrome, Radiotherapy, Non-small cell lung carcinoma

References

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Figures

Fig. 1.

Chest computed tomography shows a 3.3 cm mass with irregular margins and heterogenous density in the apical segment of the right upper lobe.

Fig. 2.

Microscopic findings show the acinar type of adenocarcinoma with malignant glands infiltrating the collagenous stroma (H&E stain, ×200).

Fig. 3.

(A) Chest computed tomography shows mediastinal lymph node enlargement after the third cycle of docetaxel. (B) The chest X-ray shows no significant changes after the 6th fraction of radiotherapy.

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