Journal List > J Lung Cancer > v.8(2) > 1050700

J Lung Cancer. 2009 Dec;8(2):111-113. Korean.
Published online December 31, 2009.
©2009 Korean Association for the Study of Lung Cancer
Primary Lung Adenocarcinoma Metastasis to the Vagina: A Case Report
Seung Yeon Ha, M.D.,1 Sanghui Park, M.D.,1 Eun Kyung Cho, M.D.,2 Soyi Lim, M.D.,3 and Jung Suk An, M.D.4
1Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
2Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
3Department of Obstetrics and Gynecology, Gachon University Gil Medical Center, Incheon, Korea.
4Department of Pathology, Sungkyunkwan University Samsung Medical Center, Seoul, Korea.

Address for correspondence: Seung Yeon Ha, M.D. Department of Pathology, Gachon University Gil Hospital, 1198, Guwol 1-dong, Namdong-gu, Incheon 405-760, Korea. Tel: 82-32-460-3078, 3073, Fax: 82-32-460-3073, Email:
Received July 24, 2009; Revised August 31, 2009; Accepted September 03, 2009.


Lung cancer is a malignant tumor that is often fatal. Vaginal metastasis of pulmonary adenocarcinoma is very rare. To the best of our knowledge, this is the second such report worldwide and the first one from Korea. A 67-year-old woman presented with cough, excessive sputum and dyspnea that she had sufferd with for the past one year and she had a palpable lesion in the vagina. Chest CT showed diffuse bronchial wall thickening involving the left main bronchus, the left upper lobar bronchus and the lingular divisional bronchus of the left upper lobe. There were multiple, various sized nodules in both lungs, of which the largest one measured about 1.0 cm in diameter. Both lung and vaginal biopsies were performed and the masses were diagnosed as adenocarcinoma. Immunohistochemically, the tumor cells were positive for cytokeratin 7 and TTF-1, but they were negative for cytokeratin 20. We present this case of primary lung adenocarcinoma metastasis to the vagina.

Keywords: Carcinoma; Lung; Vagina; Metastasis


Fig. 1
Chest CT showed the bronchial wall thickening involving the left main bronchus and the left upper lobar bronchus (arrow).
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Fig. 2
The histological findings for the lung mass: bronchoscopic biopsy showed infiltration of atypical ovoid cells with round nuclei and plump cytoplasm (inlet) (A, H&E stain, ×40). The tumor cells were positive for TTF-1 (B, TTF-1, ×200). The histological findings for the tumor cells in the vagina: microscopically, the same atypical cells of the lung (inlet) tumor had infiltrated into the vaginal stroma (C, H&E stain, ×40). These cells revealed a positive reaction for TTF-1 (D, TTF-1, ×200).
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