Pilomatrix Carcinoma with Lung and Lymph Node Metastases

Ki Uk Kim; Min Ki Lee; Yun Seong Kim; Hye Kyung Park; Chang Hoon Lee; Yeong Dae Kim; Yeon Ju Jeong; Soon Kew Park

doi:10.6058/jlc.2008.7.2.90

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Kim, Lee, Kim, Park, Lee, Kim, Jeong, and Park: Pilomatrix Carcinoma with Lung and Lymph Node Metastases

Original Article

J Lung Cancer 2008;7(2):90-92.

Published online: 10 January 2008

DOI: https://doi.org/10.6058/jlc.2008.7.2.90

Pilomatrix Carcinoma with Lung and Lymph Node Metastases

Ki Uk Kim, M.D.¹, Min Ki Lee, M.D.¹, Yun Seong Kim, M.D.¹, Hye Kyung Park, M.D.¹, Chang Hoon Lee, M.D.², Yeong Dae Kim, M.D.³, Yeon Ju Jeong, M.D.⁴, Soon Kew Park, M.D.¹

¹Departments of Internal Medicine

²Pathology

³Thoracic Surgery

⁴Radiology, Pusan National University Hospital, Busan, Korea

Address for correspondence Min Ki Lee, M.D. Department of Internal Medicine, Pusan National University Hospital, 1-10, Ami-dong, Seo-gu, Busan 602-739, Korea Tel: 82-51-240-7225 Fax: 82-51-254-3127 E-mail: leemk98@dreamwiz.com

Received 25 November 2008 Accepted 4 December 2008

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pilomatrix carcinoma is a rare locally aggressive hair-follicle tumor. We report a 54-year-old man who presented with a tumor in the left flank that was found by skin biopsy to be pilomatrix carcinoma. A contrast-enhanced computed tomographic scan of the chest, abdomen, and pelvis showed multiple small nodules in both lungs and lymphadenopathy in the abdomen. Video-assisted thoracoscopic biopsy of the lung lesions was consistent with metastatic pilomatrix carcinoma. After intravenous cisplatin and 5-fluorouracil, the skin, lung, and lymph node lesions shrank.

Keywords: Pilomatrix carcinoma, Multiple metastases, Chemotherapy

References

1. Gromiko N. Zur kenntnis der bosartigen Umwandlung des verkalkten Hautepithelioms. Arch Pathol Anat. 1927; 265:103–116.

2. Lopansri S, Mihm MC Jr. Pilomatrix carcinoma or calcifying epitheliocarcinoma of Malherbe: a case report and review of literature. Cancer. 1980; 45:2368–2373.

3. De Galvez-Aranda MV, Herrera-Ceballos E, Sanchez-Sanchez P, Bosch-Garcia RJ, Matilla-Vicente A. Pilomatrix carcinoma with lymph node and pulmonary metastasis: report of a case arising on the knee. Am J Dermatopathol. 2002; 24:139–143.

4. Bremnes RM, Kvamme JM, Stalsberg H, Jacobsen EA. Pilomatrix carcinoma with multiple metastases: report of a case and review of the literature. Eur J Cancer. 1999; 35:433–437.

5. Mir R, Cortes E, Papantoniou PA, Heller K, Muehlhausen V, Kahn LB. Metastatic trichomatricial carcinoma. Arch Pathol Lab Med. 1986; 110:660–663.

6. Niedermeyer HP, Peris K, Hofler H. Pilomatrix carcinoma with multiple visceral metastases: report of a case. Cancer. 1996; 77:1311–1314.

7. Sau P, Lupton GP, Graham JH. Pilomatrix carcinoma. Cancer. 1993; 71:2491–2498.

8. Bassarova A, Nesland JM, Sedloev T, Danielsen H, Christova S. Pilomatrix carcinoma with lymph node metastases. J Cutan Pathol. 2004; 31:330–335.

9. Forbis R Jr, Helwig EB. Pilomatrixoma (calcifying epithelio-ma). Arch Dermatol. 1961; 83:606–618.

10. Manivel C, Wick MR, Mukai K. Pilomatrix carcinoma: an immunohistochemical comparison with benign pilomatrixoma and other benign cutaneous lesions of pilar origin. J Cutan Pathol. 1986; 13:22–29.

11. Monchy D, McCarthy SW, Dubourdieu D. Malignant pilomatrixoma of the scalp. Pathology. 1995; 27:201–203.

12. Black SJ, Marple BF, Vuitch F. Multiple giant pilomatrix carcinomas of the head and neck. Otolaryngol Head Neck Surg. 1993; 109:543–547.

Figures

Fig. 1.

Initial chest CT scan showing branching opacities with tree-in-bud appearance consistent with tortuous pulmonary arteriolar dilatation by tumor embolism in both lungs.

Fig. 2.

Lung biopsy showing a nest of basaloid tumor cells with hyperchromatic, pleomorphic nuclei and small distinct nucleoli and necrotic or shadow cells in the center (Hematoxylin-eosin, ×100).

Fig. 3.

Follow-up chest CT scan after four courses of cisplatin and 5-fluorouracil demonstrating improvement of lung lesions.

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