Seok Jin Haam; Yoon Soo Chang; Hyung Jung Kim; Doo Yun Lee; Hyo Chae Paik; Se Eun Chun

doi:10.6058/jlc.2007.6.1.35

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Haam, Chang, Kim, Lee, Paik, and Chun: Photodynamic Therapy for Endobronchial Obstruction due to Recurrent Lung Cancer — 2 Cases Report

Original Article

J Lung Cancer 2007;6(1):35-37.

Published online: 10 January 2007

DOI: https://doi.org/10.6058/jlc.2007.6.1.35

Photodynamic Therapy for Endobronchial Obstruction due to Recurrent Lung Cancer — 2 Cases Report

Seok Jin Haam, M.D.¹, Yoon Soo Chang, M.D.², Hyung Jung Kim, M.D.², Doo Yun Lee, M.D.¹, Hyo Chae Paik, M.D.¹, Se Eun Chun, R.N.¹

¹Departments of Thoracic and Cardiovascular Surgery

²Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

Address for correspondence Doo Yun Lee, M.D. Department of Thoracic and Cardiovascular Surgery, Yongdong Severance Hospital, 612, Eonjuro (146-92, Dogokdong), Gangnam-gu, Seoul, Korea Tel: 82-2-2019-3385 Fax: 82-2-3461-8282 E-mail: dylee@yuhs.ac.kr

Received 15 May 2007 Accepted 30 May 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recurrent lung cancer with endobronchial obstruction after surgical resection due to lung cancer may lead to severe dyspnea, respiratory insufficiency and sudden death. Many palliative modalities including partial excision of endobronchial tumor, insertion of stent, and evaporation with laser, have been used for endobronchial obstruction due to recurrent endobronchial lung cancer. In photodynamic therapy (PDT), photosensitizer named photofrin, is infused intravenously at 48 hours before PDT, and diode laser of an appropriate wavelength is applied to induce destruction of tumor mass with 200∼250 J/ cm².　 We report 2 cases of treatment using PDT for endobronchial obstruction due to recurrent endobronchial lung cancer after surgical resection.

Keywords: Lung cancer, Endobronchial obstruction, Photodynamic therapy

References

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Fig. 1.

A 49-year-old women with recurrent left main endobronchial cancer. (A) Before photodynamic therapy, the left main bronchus was 80∼90% obstructed by endobronchial cancer. (B) After seven days of photodynamic therapy, severe dyspnea was improved because bronchial obstruction was improved due to decreased tumor mass.

Fig. 2.

A 55-year-old man with recurrent right lower endobronchial cancer. (A) Before photodynamic therapy, the right lower bronchus was near totally obstructed by endobronchial cancer. (B) After seven days of photodynamic therapy, the bronchial lumen was widened due to decreased endobronchial tumor mass.

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