Journal List > J Lung Cancer > v.5(1) > 1050657

Lee, Choi, Kim, Choi, and Kang: Comparison of the Results of Parenchymal Sparing Operation and Pneumonectomy for Non-small Cell Lung Cancer

Abstract

Purpose:

Parenchymal sparing lung surgery indicated for central tumors for which the alternative is pneumonectomy. Pneumonectomy has a higher perioperative mortality risk than lobectomy. To increase resection rates and improve outcomes we have implemented a policy of parenchymal sparing operation for tumors involving a main stem bronchus and pulmonary artery.

Materials and Methods:

From January 2000 to May 2004ô30 pneumonectomies and 30 parenchymal sparing proced䴸res were carried out in the Department of Thoracic and Cardiovascular Surgery of Ajou University Hospital. Suvival and complications were analyzed and compared. Parenchymal sparing operation was always done when technically possible. Thus pneumonectomy was reserved for lesions that could not be removed by a parenchymal sparing operation.

Results:

There were no significant inter-group differences in perioperative course or outcome and patient characteristics except postoperative stage. One year survival was 56.7% after pneumonectomy arid 86,7% after parenchymal sparing operation. The rate of pneumonectomy decreased significantly with increasing experience of parenchymal sparing operation with 21 of the last 32 patients (66%) avoiding pneumonectomy.

Conclusion:

We suggested that as a curative treatment, parenchymal sparing operation may be a safer procedure than pneumonectomy without adversely affecting outcome. Pneumonectomy can be avoided in a large proportion of patients with non-small cell lung cancer. (J Lung Cancer 2006;5{1):23-29)

REFERENCES

1.Graham EA., Singer JJ. Successful removal of an entire lung for carcinoma of the bronchus. CA Cancer J Clin. 1974. 24:238–242.
crossref
2.Price-Thomas C. Conservative resection of the bronchial tree. J R Coll Surg Edinb. 1956. 1:169.
3.Allison PR. Lobectomy and bronchial anastomosis in the surgery of bronchial carcinoma. Ann R Coll Surg Engl. 1959. 25:20.
4.Johnson JB: Jones PH. The treatment of bronchial carcinoma by lobectomy and sleeve resection of the main bronchus. Thorax. 1959. 14:48–54.
crossref
5.Tedder M., Anstadt MP: Tedder SD: Lowe JE. Current morbidity, mortality, and survival after bronchoplastic procedures for malignancy. Ann Thorac Surg. 1992. 54:387–391.
crossref
6.Lowe JE., Sabiston DC Jr. Bronchoplastic techniques in the surgical management of benign and malignant pulmonary lesions. In: Sabiston DC Jr, Spencer FC, editors. Surgery of the chest. Philadelphia: WB Saunders;. 1990. 577.
7.Okada M., Yamagishi H., Satake S, et al. Survival related to lymph node involvement in lung cancer after sleeve lobectomy compared with pneumonectomy. J Thorac Cardiovasc Surg. 2000. 119:814–819.
crossref
8.Okada M., Tsubota N., Yoshimura M, et al. Extended sleeve lobectomy for lung cancer: the avoidance of pneumonectomy. J Thorac Cardiovasc Surg. 1999. 118:710–714.
crossref
9.Ferguson MK: Lehman AG. Sleeve lobectomy or pneumonectomy: optimal management strategy using decision analysis technique. Ann Thorac Surg. 2003. 76:1782–1788.
10.Gaissert HA., Mathisen DJ., Moncure AC, et al. Survival and function after bronchial sleeve lobectomy for lung cancer. J Thorac Cardiovasc Surg. 1996. 111:948–953.
11.Rendina EA., Venuta F., de Giacomo T, et al. Parenchymal sparing operations for bronchogenic carcinoma. Surg Clin North Am. 2002. 82:589–609.
crossref
12.Suen HC., Meyers BF., Guthrie R, et al. Favorable results after sleeve lobectomy or bronchoplasty for bronchial malignancies. Ann Thorac Surg. 1999. 67:1557–1562.
crossref
13.Lausberg HF: Graeter TP., Wendler 0., Demertzis S: Ukena D., Schafers HJ. Bronchial and bronchovascular sleeve resection for treatment of central lung tumors. Ann Thorac Surg. 2000. 70:367–371.
14.Wright CD., Wain JC., Mathisen DJ., Grillo HC. Postpneumonectomy bronchopleural fistula after sutured bronchial closure: incidence, risk factors and management. J Thorac Cardiovasc Surg. 1996. 112:1367–1371.
crossref
15.Deslauriers J., Gregoire J., Jacques LF, et al. Sleeve lobectomy versus penumonectomy for lung cancer: a comparative analysis of survival and sites or recurrences. Ann Thorac Surg. 2004. 77:1152–1156.
16.Rendina EA., Venuta F: Ciriaco P., Ricci C. Bronchovascular sleeve resection. J Thorac Cardiovasc Surg. 1993. 106:73–79.
crossref
17.Weiser RD., Cooper JD: Delarue NC: Thenan TE: Todd TRJ: Pearson FG. Sleeve lobectomy for carcinoma of the lung. J Thorac Cardiovasc Surg. 1979. 78:830–849.
18.Paulson DL., Urschel HC., McNamara JJ., Shaw RR. Bronchoplastic procedures for bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1970. 59:38–48.
crossref
19.Icard P., Regnard JF., Guibert L, et al. Survival and prognostic factors in patients undergoing parenchymal saving bronchoplastic operatioin for primary lung cancer: a series of 110 consecutive cases. Eur J Cardiothorac Surg. 1999. 15:426–432.
20.Martin-Ucar AE: Chaudhuri N., Edward JG., Waller DA. Can pneumonectomy for non-small cell king cancer be avoided? An audit of parenchymal sparing lung surgery. Eur J Cardiothorac Surg. 2002. 21:601–605.
21.Cho SK., Sung KI., Lee C, et al. Long term results of bronchial sleeve resection for primary lung cancer, Korean J Thorac Cardiovasc Surg. 2001. 34:917–923.

Fig. 1.
Avoidance of pneumonectomy with experience.
jlc-5-23f1.tif
Fig. 2.
Survival curve.
jlc-5-23f2.tif
Table 1.
Demographic Characteristics
  Pneumonectomy Sleeve resection
No. cases 30 30
Age 63.16±7.94 63.23 ±8.50
Men : Women 25 : 5 28 : 2
FEV1 2.08±0.48 2.01±0.57
FEV1% 84,30±24.13 86.62±28.32
FEV1%<70 7 (23%) 10 (33%)
Op. time 203.90±52.79 249.33±64.49
POD 25.44±39.96 13.82±6.29
Table 2.
Broncho plastic Procedures Performed
  No. of patients (%)
Left upper lobe 6 (20)
Left lower lobe 6 (20)
Right upper lobe 11 (37)
Upper bilobectomy 2 (6.5)
Lower bilobectomy 3 (10)
Right lower lobe 2 (6.5)
Total 30 (100)
Table 3.
Postoperative Complications for both Procedures
  Pneumonectomy Sleeve resection
Mortality 3 0
Pneumonia 4 1
Atelectasis 0 7
Arrhythmia 1 3
BPF 1 1
Prolonged air leak 0 2
Chylothorax 1 1
ARDS (PRE) 3 0
Table 4.
Annual Cases
Year Pneumonectomv Sleeve resection
2000 10 2
2001 9 7
2002 1 5
2003 6 10
2004 4 6
Table 5.
Distribution of Histoogy in Both Group
Histologic diagnosis Pneumonectomy Sleeve resection
Squamous carcinoma 21 23
Adenocarcinoma 8 2
Brorichioalveolar 1 0
Large cell carcinoma 0 2
Adenosquamous 0 1
Adenoid cystic carcinoma 0 2
Table 6.
Distribution of Pathologic Stages
  Pneumonectomv Sleeve resection
IA 0 1
IB 6 14
IIB 10 11
IIIA 5 4
IIIB 5 0
IV 4 0
TOOLS
Similar articles