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Abstract
Purpose
Lung cancer has been the leading cause of death in South Korea since the year 2000. Adenocarcinoma became the most frequent type in the national survey of lung cancer since year 2005.
Materials and Methods
We analyzed 5,456 cases with lung cancer from 2004 to 2012 in a community cancer center. The mean age was 69.9 years, and 78.9% was male.
Results
Adenocarcinoma (ADC, 40.8%) was the most frequent type, followed by squamous cell carcinoma (SQC, 36.4%), small cell carcinoma (SCC, 14.8%) and non-small cell lung cancer (NSCLC) not otherwise specified (8.1%). In male patients, SQC was the most frequent type (43.5%), while ADC showed highest incidence in females (72.6%). Anatomic stage at diagnosis in NSCLC was I (10.3%), II (5.8%), IIIA (15.7%), IIIB (19.2%), and IV (49.0%). In SCC, 41.7% was in limited stage and 58.3% was diagnosed in extensive stage. The proportion of never smoker has been increased from 19.1% in 2004~2008 to 25.4% in 2009~2012. Never-smokers are more likely to be female (68.2% vs. 4.0%, p<0.001), have ADC (69.9% vs. 31.3%, p<0.001), and manifest as stage IV disease (58.5% vs. 45.2%, p<0.001), compared to smokers. Among 1,908 cases whose initial treatment was recorded, 42.5% received chemotherapy, 25.7% received radiation treatment, 20.5% received surgery and the remaining 11.3% received supportive cares only or transferred to other health care facilities.
Figures and Tables
Fig. 1
Proportion of lung cancer histologic types from year 2004 to 2012. ADC: adenocarcinoma, NSC: non-small cell carcinoma, not otherwise specified, SCC: small cell carcinoma, SQC: squamous cell carcinoma.
Fig. 2
Proportion of stage (I, II, IIIA, IIIB, and IV) at diagnosis in squamous cell carcinoma (SQC; 8.9%, 7.3%, 22.8%, 28.0%, 33.0%) and adenocarcinoma (ADC; 12.3%, 4.5%, 10.5%, 11.2%, 61.5%; p<0.001).
Fig. 3
Histologic type according to smoking history. ADC: adenocarcinoma, SQC: squamous cell carcinoma, NSC: non-small cell carcinoma, not otherwise specified, SCC: small cell carcinoma.
Fig. 4
Proportion (%) of initial treatment modalities for 1908 cases with lung cancer. BSC: best supportive care.
References
1. Korea National Statistical Office. Death rate statistics of Korea, 2011. 2012. Daejeon: Korea National Statistical Office.
2. In KH, Kwon YS, Oh IJ, et al. Lung cancer patients who are asymptomatic at diagnosis show favorable prognosis: a Korean Lung Cancer Registry Study. Lung Cancer. 2009. 64:232–237.
3. Kim YC, Kwon YS, Oh IJ, et al. National survey of lung cancer in Korea, 2005. J Lung Cancer. 2007. 6:67–73.
4. National Lung Screening Trial Research Team. Aberle DR, Adams AM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011. 365:395–409.
5. Lee C, Kang KH, Koh Y, et al. Characteristics of lung cancer in Korea, 1997. Lung Cancer. 2000. 30:15–22.
6. Yano T, Miura N, Takenaka T, et al. Never-smoking nonsmall cell lung cancer as a separate entity: clinicopathologic features and survival. Cancer. 2008. 113:1012–1018.
7. Bryant A, Cerfolio RJ. Differences in epidemiology, histology, and survival between cigarette smokers and never-smokers who develop non-small cell lung cancer. Chest. 2007. 132:185–192.
8. Ferketich AK, Niland JC, Mamet R, et al. Smoking status and survival in the national comprehensive cancer network non-small cell lung cancer cohort. Cancer. 2012. 09. 28. [Epub]. http://dx.doi.org/10.1002/cncr.27824.
9. NCCN Clinical Practice Guidelines in Oncology, Lung Cancer Screening [Internet]. 2012. cited 2012 Aug 1. Fort Washington: National Comprehensive Cancer Network;Available from: http://www.nccn.com/patient-guidelines.html.
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