To the Editor: In his review "Acid-Base Disorders in lCU Patients, Oh1) writes in the summary on p 66 "The treatment target ... is not the acidosis, but the underlying condition causing acidosis". In contrast to this statement, Edge et al.2) have concluded that the immediate cause of coma in patients with acidosis is the very low blood pH. The glycolytic enzyme phosphofructokinase is pH dependent, as its activity is decreasing with decreasing pH, and, thus, glucose utilization in brain cells is impaired3). For the readers of "Electrolyte Blood Press" it would be perhaps interesting to know, why the author did not comment the paper of Edge et al.2).