From August 2006 and September 2010, 186 patients with pelvic fractures were referred to our trauma center. Of these, 15 cases with associated perineal injury were eligible to participate in this study. In the emergency department, all the patients were managed according to the standard Advanced Trauma Life Support (ATLS) protocol13) and antibiotics and anti-tetanus protocol were injected appropriately. Management course was different for each patient depending on his/her hemodynamic status.

Of the 15 patients, there were 12 men (80%) and 3 women (20%); their mean age was 38.6 years (range, 11 to 65 years). Ten patients were admitted within 6 hours after the accident while the rest were delayed up to 12 hours. The mechanisms of injury, No. of patients of pelvic fractures (according to Young-Burgess classification5)) and ISS in our patients were depicted in Table 1. The mean ISS in our patients was 29 (range, 11 to 61).

Injuries associated with these open pelvic fractures are depicted in Table 2. Two patients (13.3%) died; the first with a type III anteroposterior compression (APC) pelvis fracture was due to uncontrolled hemorrhagic shock, while the latter was due to septicaemia. We had one case with acute renal failure which improved with medical treatment. One patient (6.6%) had sciatic nerve palsy associated with type II lateral compression (LC) pelvis fracture. Five hemodynamically unstable patients (33%) underwent explorative laparotomy for suspected intra-abdominal injuries. All of these patients had intra-abdominal fluid based on FAST examination. Three of them had large expanding pelvic hematoma and two had spleen injury.

All the patients underwent colostomy (with sigmoid loop) and six patients (40%) underwent cystostomy due to urogenital injury. All hemodynamically stable and unstable patients had surgical stabilization of the pelvis within three hours from the arrival in the emergency department. In this procedure, we used an external fixator alone in 7 patients and an external fixator associated with a posterior fixation device (like plate or cannulated screw) in 8 patients.

Transfusions were required in all 15 patients. The average amount of blood transfused was 8 packed red blood cell units (range, 4 to 21 units). Two patients with APC type III fractures were in deep shock; one patient received 21 units of blood and survived but the latter received 18 units and postoperatively died due to his associated intra-abdominal injury. Thirteen patients (86.7%) received more than four liters of ringer lactate serum and 6 units of blood on the first day of admission.

Daily irrigation and debridement of the perineal wound were performed in all the patients. The mean length of stay in intensive care unit (ICU) and hospital were 7.4 days (range, 1 to 24 days) and 19.6 days (range, 8 to 36 days), respectively. In comparison to LC type, APC type fractures were associated with higher length of stay in hospital and ICU, and higher ISS. At the last follow-up visit, 12 patients (80%) with surgically treated unstable open pelvic fracture have returned to their original work without further significant disability, and only one patient changed his previous job.

Open pelvic fractures are caused by high energy trauma and are commonly associated with many other injuries. These injuries often increase the rates of morbidity and mortality relative to closed ones. Literature reported mortality rates in open pelvic fractures varied up to 50%.4,7,10) In our study, a defined resuscitation and pelvic fixation strategy initiated by a multidisciplinary approach team comprised of at least an orthopedic surgeon, a general surgeon, and an anesthesiologist resulted in better outcomes and less mortality rate of 13.3%.

Some authors have based their treatment protocol on the initial FAST, radiographic findings, and the presence or absence of hemodynamic shock.14) Recently, it has been shown that immediate computerized tomography scanning in these multiple injured patients significantly accelerated proper diagnosis and targeted treatment interventions.1)

Because of the high correlation between the mortality rate and initial hemodynamic status, we based our treatment protocol on the hemodynamic status.11,15) It is often quoted that the amount of blood and serum transfusion has a direct correlation with the amount of organ injuries and the mean blood transfusion requirement is around 5 to 8 units in these pelvic fractures.16) The rate is similar to our study (8 units).

APC type fractures compared with LC type or vertical shear, were found to have a higher risk of bleeding, while LC type fractures have the lowest. APC fractures also have a higher rate of mortality.2,4) The results we obtained from this study also confirmed this.

Pelvic stability should be achieved immediately after injury because it has a vital role in the resuscitation of hemodynamically unstable patients.17) Therefore, one of the first important measures in dealing with these open pelvic fractures is to fix the underlying cause of bleeding (from the chest, abdomen, or other sites) while simultaneously resuscitating the patient from shock by appropriate serum, blood elements, and electrolytes replacement.18) Pelvic bleeding control should be obtained by surgical exploration and/or early pelvic stabilisation. Early pelvic stabilisation has been shown to control bleeding and improve outcomes efficiently.19-21) Emergency pelvic stabilization has led to increased survival after pelvic fracture.22) Pelvic fixation by an external fixator device not only stabilizes the pelvis bones but also secures the tamponade effect of the haematoma in an ongoing venous bleeding place. Pelvic anti-shock clamp may also be used to stabilize posterior pelvic ring to limit pelvic ring expansion and control continuous bleeding.

Anterior external fixation is a useful technique easily applicable in urgent situations to reduce pelvic volume and control haemorrhage; however, proper anatomic reduction and stabilization of the posterior part of the pelvis may not be easily achieved by this and lead to chronic pain and long-term morbidity.19,20) Early pelvic stabilization controls instability, decreases bleeding, diminishes risk of chronic pain and allows early patient mobilization. There are numerous techniques with variable success for pelvic fracture fixation including anterior plate stabilisation, posterior iliosacral screw or plate fixation and so on.23,24) In this study we used an anterior external fixator with or without the posterior plating or screw fixation as soon as possible. Seven patients had anterior fixation alone with an external fixator while eight patients had combined anterior and posterior fixations.

The high probability of pelvic sepsis and multi-organ failure in open pelviperineal injuries has been frequently reported.25,26) It has been noted that pelvic sepsis is associated with 21% mortality.26) In these pelviperineal injuries, early fecal diversion (colostomy) with repeated aggressive irrigation and debridement have substantial preventive effects on pelvic sepsis,26) although colostomy increases the length of hospitalization.27) In the study we carried out, colostomy was performed in all the patients and we had three patients with pelvic infections and one sepsis and death. However, daily irrigation and debridement were done for all the patients.

One of the weaknesses of our study was the relatively small number of patients, but it should be mentioned that these severe orthopedic injuries are not so common. Therefore, careful evaluation and analysis of these potentially fatal injuries are important. Another drawback of our research was its retrospective nature. To provide more accurate recommendations we propose a stronger prospective study on a larger number of patients. In conclusion, open pelvic fractures with extensive perineal injury are associated with high mortality rate. Early diagnosis and appropriate treatment, including reanimation, colostomy, cystostomy, vigorous and repeated irrigation and debridement, and fixation by an external fixator may improve the outcome and reduce the mortality rate.