The effect of vitamin-C containing neutraceutical on periodontal wound healing as an adjunct to non-surgical or surgical periodontal treatment

Young-Ran Baek; Jin-Woo Park; Jae-Mok Lee; Jo-Young Suh

doi:10.5051/jkape.2009.39.2.157

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Baek, Park, Lee, and Suh: The effect of vitamin-C containing neutraceutical on periodontal wound healing as an adjunct to non-surgical or surgical periodontal treatment

Original Article

The Journal of the Korean Academy of Periodontology

The Journal of the Korean Academy of Periodontology 2009; 39(2): 157-166.

Published online: 30 June 2009

DOI: https://doi.org/10.5051/jkape.2009.39.2.157

The effect of vitamin-C containing neutraceutical on periodontal wound healing as an adjunct to non-surgical or surgical periodontal treatment

Young-Ran Baek, Jin-Woo Park, Jae-Mok Lee, Jo-Young Suh

Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu, Korea.

Correspondence: Jo-Young Suh, D.D.S Ph.D. Department of Periodontology, School of Dentistry, Kyungpook National University, 188-1, Samduk-dong 2ga, Jung-gu, Daegu 700-412, Korea. jysuh@knu.ac.kr, Tel: 82-53-600-7521, Fax: 82-53-427-3263

Received 7 April 2009 Accepted 2 June 2009

Abstract

Purpose

There are numerous reports about the usefulness of antibiotics such as doxycycline or metronidazole in the conventional treatment for the patients with chronic periodontal diseases. However, seldom are the reports about effects of vitamins or nutraceuticals. The purpose of this study was to evaluate the effects of nutrient supplement including multiple vitamins and neutraceuticals with PRF-K2 from plants and seaweed in treatment of the patients with chronic periodontitis which is needed a nonsurgical or a surgical treatment by evaluating the clinical parameters and the gingival crevicular fluid volume.

Methods

The systemically healthy and nonsmoking patients diagnosed with chronic periodontitis were divided into a nonsurgical group and a surgical group. They were also divided into the test group with nutrient supplements and the control group without nutrient supplements. In the nonsurgical group, the clinical parameters (probing depth, clinical attachment level, sulcus bleeding index, and plaque index) and the gingival crevicular fluid volume were checked on baseline, at 1 week, at 3 week and at 9 week after a supplement treatment. In the surgical group, the clinical parameters and the gingival crevicular fluid volume were also checked at 15 week after a surgical treatment.

Results

In both nonsurgical and surgical groups, reduction of pocket depth and increment of clinical attachment level were revealed in the test group compared with the control group, but there was not statistically significant difference (p>0.05), and sulcus bleeding index was decreased with statistically significant difference (p<0.05). In addition, plaque index was decreased with statistically significant difference (p<0.05) in the nonsurgical group. Gingival crevicular fluid volume was decreased with statistically significant difference (p<0.05) at week 9 in both non-surgical and surgical groups.

Conclusions

In conclusion, our results demonstrate that providing nutrient supplement in both nonsurgical or surgical periodontal treatments may improve gingival inflammation and gingival crevicular fluid.

Keywords: ascorbic acid, dietary supplements, periodontitis, gingvial crevicular fluid

Figures and Tables

Figure 1

Study design of non-surgical group (GCF, gingival crevicular fluid; PD, pocket depth; CAL, clinical attachment level; SBI, sulcus bleeding index; PI, plaque index; OHI, oral hygiene instruction).

Figure 2

Study design of surgical group (GCF, gingival crevicular fluid; PD, pocket depth; CAL, clinical attachment level; SBI, sulcus bleeding index; PI, plaque index; OHI, oral hygiene instruction; FO. flap operation).

Table 1

The Demographic Characteristics of Subjects in Non-surgical Group

Table 2

The Demographic Characteristics of Subjects in Surgical Group

Table 3

Whole-Mouth Clinical Parameters for Test and Control Groups in Non-surgical group (Mean±SD)

^*significant difference compared to baseline (p<0.0167), ⁺significant difference compared to control group (p<0.05)

Table 4

Clinical Parameters for Maxilla and Mandible in Test Group of Non-surgical Group (Mean±SD)

^*significant difference compared to baseline (p<0.0167), ⁺significant difference compared to Mn (p<0.05)

Table 5

Clinical Parameters for Anterior and Posterior Segments in Test Group of Non-surgical Group (Mean±SD)

^*significant difference compared to baseline (p<0.0167), ⁺significant difference compared to Ant. segment (p<0.05)

Table 6

Whole-Mouth Clinical Parameters for Test and Control groups in Surgical Group (Mean±SD)

^*significant difference compared to baseline (p<0.0125), ⁺significant difference compared to control group (p<0.05)

Table 7

Clinical Parameters for Maxilla and Mandible in Test Group of Surgical Group (Mean±SD)

^*significant difference compared to baseline (p<0.0125), ⁺significant difference compared to Mn (p<0.05)

Table 8

Clinical Parameters for Anterior and Posterior Segments in Test Group of Surgical Group (Mean±SD)

^*significant difference compared to baseline (p<0.0125), ⁺significant difference compared to Ant. segment (p<0.05)

Table 9

Gingival Crevicular Fluid Volume of Study Sites in Test and Control Group of Non-surgical Group (Mean±SD)

^*significant difference compared to baseline (p<0.0167), ⁺significant difference compared to control group (p<0.05)

Table 10

Gingival Crevicular Fluid Volume of Study Sites in Test and Control Group of Surgical Group (Mean±SD)

^*significant difference compared to baseline (p<0.0125), ⁺significant difference compared to control group (p<0.05)

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