Clinical study of guided bone regeneration of extracted socket with PLA/PGA membrane and silk fibroin membrane

Woo-Jin Hwang; Seong-nyum Jeong; Yun-Sang Kim; Sung-Hee Pi; Hyung-Keun You; Chong-pyoung Chung; Hyung-Shik Shin

doi:10.5051/jkape.2009.39.2.129

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Hwang, Jeong, Kim, Pi, You, Chung, and Shin: Clinical study of guided bone regeneration of extracted socket with PLA/PGA membrane and silk fibroin membrane

Original Article

The Journal of the Korean Academy of Periodontology

The Journal of the Korean Academy of Periodontology 2009; 39(2): 129-138.

Published online: 30 June 2009

DOI: https://doi.org/10.5051/jkape.2009.39.2.129

Clinical study of guided bone regeneration of extracted socket with PLA/PGA membrane and silk fibroin membrane

Woo-Jin Hwang¹, Seong-nyum Jeong¹, Yun-Sang Kim¹, Sung-Hee Pi¹, Hyung-Keun You¹, Chong-pyoung Chung^2,³, Hyung-Shik Shin¹

¹Department of Periodontology, School of Dentistry, Wonkwang University, Iksan, Korea.

²Department of Periodontology, School of Dentistry, Seoul National University, Seoul, Korea.

³NIBEC Inc., Korea.

Correspondence: Dr. Shin Hyung-Shik. Department of Periodontology, School of Dentistry, Wonkwang University #344-2, Sinyong-Dong, Iksan City, Jeollabukdo, South Korea, 435-035. periohs@wonkwang.ac.kr, Tel: 82-63-859-2967, Fax: 82-63-857-6364

Received 29 January 2009 Accepted 21 May 2009

Abstract

Purpose

This study was designed to compare the bond regeneratiom effects of treatment using silk fibroin membrane ( Nanogide-S®) resorbable barrier with control group treated by polyactic acid / polylacticglycolic acid membrane(Biomesh®).

Methods

44 severe bone loss on extraction socket from 44 patients were used in this study. In experimental group 22 sites of them were treated by silk fibrin membrane as and the other 22 sites were treated by polyactic acid/ polylacticglycolic acid membrane as a control group. Clinical parameters including recovered bone width, length and radiographic parameter of vertical length were evlauated at base line and 3 months after surgery.

Results

1) Severe bone width, length was significantlly decreased in two group. 2) Bone width, length was significantlly decreased in two group. 3) Decreased bone width, length and radiographic examination differences between group.

Conclusions

On the basis of these results, silk fibrin resorbable membrane has similar bone regeneration ability to polyactic acid / polylacticglycolic acid membrane in guided bone regeneration for severe bone loss defect on extraction socket.

Keywords: fibroin, polylactic acid-polyglycolic acid copolymer, regeneration

Figures and Tables

Figure 1

Comparison of mesio-distal width of bone defects according to treatment period(Mean±S.D, mm).

Figure 2

Comparison of bucco-lingual width of bone defects according to treatment period(Mean±S.D, mm).

Figure 3

Comparison of radiographic depth of bone defects according to treatment period(Mean±S.D,mm).

Table 1

Comparison of Mesio-distal Width of Bone Defects According to Treatment Period(Mean±S.D, mm)

^*Significantly different from base line(p<0.05).

Table 2

Comparison of Bucco-lingual Width of Bone Defects According to Treatment Period(Mean±S.D,mm)

^*Significantly different from base line(p<0.05).

Table 3

Comparison of Radiographic Depth of Bone Defects According to Treatment Period(Mean±S.D, mm)

^*Significantly different from base line(p<0.05).

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