Journal List > J Korean Acad Periodontol > v.38(1) > 1049775

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Lee, Jang, Lee, Suh, and Park: Histomorphometric evaluation of bone healing with natural calcium carbonatederived bone substitutes in rat calvarial defect
Original Article

The Journal of the Korean Academy of Periodontology 2008; 38(1): 83-90.

Published online: 31 March 2008

DOI: https://doi.org/10.5051/jkape.2008.38.1.83

Histomorphometric evaluation of bone healing with natural calcium carbonatederived bone substitutes in rat calvarial defect

Chung-Ho Lee1, Je-Hee Jang2, Jae-Mok Lee1, Jo-Young Suh1, Jin-Woo Park1

1Department of Periodontology, School of Dentistry, Kyungpook National University, Korea.

2Department of Periodontology, Graduate School of Dentistry, Kyungpook National University, Korea.

Correspondence: Dr. Jin-Woo Park. Department of Periodontology, School of Dentistry, Kyungpook National University, 188-1, Samduk 2Ga, Jung-Gu, Daegu 700-412, Korea. jinwoo@knu.ac.kr, Tel: 82-53-420-5954, Fax: 82-53-257-6883

Received 3 March 2008       Accepted 12 March 2008

Copyright © 2008 Korean Academy of Periodontology

Abstract

Purpose

This study investigated the osteoconductivity of natural calcium carbonate-derived bone substitutes, hen eggshell (ES), and compared with those of commercial bone substitutes.

Materials and Methods

Osseous defects created in the rat calvaria were filled with particulated ES(ES-1), ES with calcium-deficient hydroxyapatite surface layer (ES-2), Biocoral(Inoteb, France), and Bio-Oss(Geistlich Pharma, Wolhusen, Switzerland). After 4 and 8 weeks of healing, histomorphometic analysis was performed to evaluate the amount of newly formed mineralized bone area (NB%).

Results

Histologic and histomorphometric analysis showed new bone formation and direct bony contact with the grafted materials in all groups. At 4 weeks, Biocoral group showed greater NB% compared to Bio-Oss and ES-1 groups (P<0.05). At 8 weeks, Biocoral and ES-2 groups showed significantly greater NB% compared to Bio-Oss group (P<0.05).

Conclusion

These results indicate that natural calcium carbonate-derived bone substitutes with microporous calcium-deficient hydroxyapatite surface layer may be an effective materials treating osseous defects.

Keywords: bone substitute, calcium carbonate, osteoconductivity, histomorphometry

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