Journal List > J Korean Acad Periodontol > v.38(1) > 1049768

TOOLS
Yang, Chae, Yun, Jung, Lee, Cho, Chai, Kim, and Choi: Study of chitosan's effects on periodontal tissue regeneration: a meta-analysis of the histomorphometry
Original Article

The Journal of the Korean Academy of Periodontology 2008; 38(1): 7-14.

Published online: 31 March 2008

DOI: https://doi.org/10.5051/jkape.2008.38.1.7

Study of chitosan's effects on periodontal tissue regeneration: a meta-analysis of the histomorphometry

Jin-Hyuk Yang1, Gyung-Joon Chae1, Jeong-Ho Yun3, Ui-Won Jung1, Yong-Keun Lee2, Kyoo-Sung Cho1, Jung-Kiu Chai1, Chong-Kwan Kim1, Seong-Ho Choi1

1Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea.

2Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Korea.

3Department of Dentistry, College of Medicine, Kwandong University, Myongji Hospital, Gyeonggi, Korea.

Correspondence: Seong-Ho Choi. Department of Periodontology, School of Dentistry, Yonsei University, 134 Shin-Chon dong, Seodaemoon-gu, Seoul, 120-752, Korea. shchoi726@yumc.yonsei.ac.kr, Tel: 82-2-2228-3189, Fax: 82-2-392-0398

Received 20 December 2007       Accepted 27 December 2007

Copyright © 2008 Korean Academy of Periodontology

Abstract

Purpose

Chitosan & chitosan derivative(eg. membrane) have been studied in periodontal regeneration, and recently many studies of chitosan have reported good results. If chitosan's effects on periodontal regeneration are enhanced, we can use chitosan in many clinical and experimental fields. For this purpose, this study reviewed available literatures, evaluated comparable experimental models.

Materials and Methods

Ten in vivo studies reporting chitosan's effects on periodontal tissue regeneration have been selected by use of the 'Pubmed' and hand searching.

Results

1. In Sprague Dawley rat calvarial defect models, amount of newly formed bone in defects showed significant differences between chitosan/chitosan-carrier/chitosan-membrane groups and control groups.
2. In beagle canine 1-wall intrabony defect models, amount of new cementum and new bone showed significant differences between chitosan/chitosan-membrane groups and control groups.
The mean values of the above experimental groups were greater than the control groups.

Conclusion

The results of this study have demonstrated that periodontal regeneration procedure using chitosan have beneficial effects, which will be substitute for various periodontal regenerative treatment area. One step forward in manufacturing process of chitosan membrane and in use in combination with other effective materials(eg. bone graft material or carrier) may bring us many chances of common use of chitosan in various periodontal area.

Keywords: chitosan, periodontal regeneration, calvarial defect, 1 wall defect

TOOLS
Similar articles