Journal List > J Korean Acad Periodontol > v.38(2) > 1049707

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Kim, Kwon, Park, Chung, and Herr: The effect of micro-macroporous biphasic calcium phosphate incorporated with polyphosphate on exophytic bone regeneration
Original Article

The Journal of the Korean Academy of Periodontology 2008; 38(2): 179-190.

Published online: 30 June 2008

DOI: https://doi.org/10.5051/jkape.2008.38.2.179

The effect of micro-macroporous biphasic calcium phosphate incorporated with polyphosphate on exophytic bone regeneration

Dong-Hwan Kim1, Young-Hyuk Kwon1, 2, Joon-Bong Park1, 2, Jong-Hyuk Chung1, 2, Yeek Herr1, 2

1Department of Periodontology, School of Dentistry, Kyung Hee University, Korea.

2Institute of Oral Biology, School of Dentistry, Kyung Hee University, Korea.

Correspondence: Dr. Yeek Herr. Department of Periodontology, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Korea. yherr@khu.ac.kr, Tel: 82-2-958-9380, Fax: 82-2-958-9387

Received 20 May 2008       Accepted 6 June 2008

Copyright © 2008 Korean Academy of Periodontology

Abstract

Purpose

In this study, the effect of micro-macroporous biphasic calcium phosphate(MBCP) incorporated with inorganic polyphosphate for bone regeneration in the calvaria of rabbit was evaluated.

Materials and Methods

The procedure of guided bone regeneration was performed with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. Four animal groups were compared : 1) TR-ePTFE membrane for negative control group, 2) TR-ePTFE membrane filled with MBCP for positive control group, 3) TR-ePTFE membrane filled with MBCP soaked in 4% inorganic polyphosphate for experimental group I, and 4) TR-ePTFE membrane filled with MBCP soaked in 8% inorganic polyphosphate for experimental group II.

Results

1. Negative control group showed the highest new bone formation at 16 weeks.
2. Positive control group showed the smallest new bone formation compared to other groups.
3. 8% inorganic polyphosphate induced more volume of bone formation, otherwise experimental group II did not show significant difference compared to negative control group.

Conclusion

These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration, possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue.

Keywords: MBCP, polyphosphate, exophytic bone regeneration

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