Journal List > J Korean Acad Periodontol > v.37(Suppl) > 1049657

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Lee, Lim, Chae, Jung, Kim, Lee, Cho, Chai, Kim, and Choi: Effects of various membranes on periodontal tissue regeneration: a meta-analysis of the histomorphometry
Original Article

The Journal of the Korean Academy of Periodontology 2007; 37(3): 465-478.

Published online: 30 September 2007

DOI: https://doi.org/10.5051/jkape.2007.37.3.465

Effects of various membranes on periodontal tissue regeneration: a meta-analysis of the histomorphometry

Jung-Seok Lee1, Hyun-Chang Lim1, Gyung-Joon Chae1, Ui-Won Jung1, Chang-Sung Kim1, Yong-Keun Lee2, Kyoo-Sung Cho1, Jung-Kiu Chai1, Chong-Kwan Kim1, Seong-Ho Choi1

1Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea.

2Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Korea.

Corresponding Author (shchoi726@yumc.yonsei.ac.kr)

Copyright © 2007 Korean Academy of Periodontology

Abstract

Various periodontal barrier membranes used in many clinical and experimental fields, and many recent studies of membranes have reported good results. To improve clinical results, selection of barrier membranes is an important factor. So, we need not only to evaluate various barrier membranes, but also to understand the property of barrier membranes appropriate to defect characteristics.
For this purpose, this study reviewed available literature, evaluated comparable experimental models, and compared various barrier membranes. From above mentioned methods, the following conclusions are deduced.

  1. In 1-wall periodontal defect models, new bone formation showed a consistent result, almost 30% of the defect size. New cementum formations measured mostly 40% of the defect size, but showed more variations than new bone formations. This seems to be resulted form difference in experimental methods, so standardization in experimental methods is needed for future studies.

  2. Application PLGA barrier membrane to periodontal defect demonstrated improved healing in new bone and new cementum.

  3. There was a minimal periodontal regeneration with calcium sulfate barrier membrane only. But, there was better healing pattern in combination of calcium sulfate membrane with bone graft material, such as DFDBA.

  4. There was no significant difference between the experimental group that used chitosan membrane only and the control group. But, in combination with bone graft material for space maintanence, periodontal regeneration was improved.

Overall, Space maintenance is a critical factor for Guided tissue regeneration using barrier membranes. Also, a barrier membrane itself that has difficulty in maintaining space, achieved better result when used with graft material.

Keywords: membrane, chitosan, calcium sulfate, PLGA, GTR, 1-Wall defect

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