Journal List > J Korean Acad Periodontol > v.36(2) > 1049568

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Ryu, Park, Kwon, Herr, Chung, and Jue: Histologic evaluation of the regenerated bone using bone graft materials
Original Article

The Journal of the Korean Academy of Periodontology 2006; 36(2): 289-303.

Published online: 30 June 2006

DOI: https://doi.org/10.5051/jkape.2006.36.2.289

Histologic evaluation of the regenerated bone using bone graft materials

Ho-Chul Ryu1, Joon-Bong Park1, Young-Hyuk Kwon1, Yeek Herr1, Jong-Hyuk Chung1, Seong-Suk Jue2

1Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, Korea.

2Department of Oral Anatomy, School of Dentistry, Kyung Hee University, Seoul, Korea.

Corresponding author (jbpark@khu.ac.kr)

Copyright © 2006 Korean Academy of Periodontology

Abstract

This study was performed to evaluate the effect of bone graft materials including demineralized freeze-dried bone, freeze-dried bone, deproteinized bovine bone on space-making capacity and bone formation in guided bone regeneration with titanium reinforced ePTFE membrane(TR-ePTFE). Adult male rabbits(mean BW 2kg) were used in this study. Intramarrow penetration defects were surgically created with round bur on calvaria of rabbits. TR-ePTFE membrane was adapted to calvarial defect and bone graft materials were placed. Animals were sacrificed at 2, 8, 12 weeks after surgery. Non-decalcified specimens were processed for histologic analysis and prepared with Villaneuva bone stain.
The results of this study were as follows:
1. TR-ePTFE membrane was biocompatible and capable of maintaining the space-making.
2. Tissue integration was not good at TR-ePTFE membrane. Fixation was not enough. So, wound stabilization was not good.
3. In animals using deproteinized bovine bone, demineralized freeze-dried bone, bone formation was little.
4. In animals using freeze-dried bone, bone formation was better.
Within the above results, bone formation may be inhibited when wound stabilizafion was not good.

Keywords: Guided bone regeneration, Titanium reinforced ePTFE membrane, Bone graft materials

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