Journal List > J Korean Acad Periodontol > v.36(2) > 1049568

Ryu, Park, Kwon, Herr, Chung, and Jue: Histologic evaluation of the regenerated bone using bone graft materials

Abstract

This study was performed to evaluate the effect of bone graft materials including demineralized freeze-dried bone, freeze-dried bone, deproteinized bovine bone on space-making capacity and bone formation in guided bone regeneration with titanium reinforced ePTFE membrane(TR-ePTFE). Adult male rabbits(mean BW 2kg) were used in this study. Intramarrow penetration defects were surgically created with round bur on calvaria of rabbits. TR-ePTFE membrane was adapted to calvarial defect and bone graft materials were placed. Animals were sacrificed at 2, 8, 12 weeks after surgery. Non-decalcified specimens were processed for histologic analysis and prepared with Villaneuva bone stain.
The results of this study were as follows:
1. TR-ePTFE membrane was biocompatible and capable of maintaining the space-making.
2. Tissue integration was not good at TR-ePTFE membrane. Fixation was not enough. So, wound stabilization was not good.
3. In animals using deproteinized bovine bone, demineralized freeze-dried bone, bone formation was little.
4. In animals using freeze-dried bone, bone formation was better.
Within the above results, bone formation may be inhibited when wound stabilizafion was not good.

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