Journal List > J Korean Acad Periodontol > v.35(2) > 1049494

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Park, Han, Kim, Lee, Park, Lee, Kim, Seol, Ku, Rhyu, Han, and Chung: A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B)
Original Article

The Journal of the Korean Academy of Periodontology 2005; 35(2): 335-343.

Published online: 30 June 2005

DOI: https://doi.org/10.5051/jkape.2005.35.2.335

A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B)

Ho-Nam Park1, Sang-Hyuk Han5, Kyoung-Hwa Kim1, 4, Sang-Chul Lee5, Yoon-Jeong Park2, 4, 5, Sang-Hoon Lee3, 4, Tae-Il Kim1, Yang-Jo Seol1, Young Ku1, 4, In-Chul Rhyu1, Soo-Boo Han1, Chong-Pyoung Chung1, 4, 5

1Department of Periodontology, College of Dentistry, Seoul National University, Korea.

2Craniomaxillofacial Reconstructive Science Major, College of Dentistry, Seoul National University, Korea.

3Department of Dental Biomaterials Sciences, College of Dentistry, Seoul National University, Korea.

4Intellectual Biointerface Engineering Center, KOSEF, Korea.

5NIBEC Inc., Korea.

Corresponding Author (ccpperio@snu.ac.kr)

Copyright © 2005 Korean Academy of Periodontology

Abstract

Inorganic bovine bone mineral has been widely researched as bone substitution materials in orthopedic and oral and maxillofacial application. OCS-B(NIBEC, Korea) is newly-developed inorganic bovine bone mineral. The aim of this study is to evaluate the safety and efficacy of bovine bone-derived bone graft material(OCS-B).
Micro-structure of newly-developed inorganic bovine bone mineral(OCS-B) was analyzed by scanning electron microscope(SEM). Round cranial defects with eight mm diameter were made and filled with OCS-B in rabbits. OCS-B was inserted into femoral quadrant muscle in mouse. In scanning electron microscope, OCS-B was equal to natural hydroxyapatite. Rabbits were sacrificed at 2 weeks and 4 weeks after surgery and mice were sacrificed at 1 week and 2 weeks after surgery. Decalcified specimens were prepared and observed by microscope. In calvarial defects, osteoid and new bone were formed in the neighborhood of OCS-B at 2 weeks after surgery. And at 4 weeks after surgery osteoid and new bone bridge formed flourishingly. No inflammatory cells were seen on the surface of OCS-B at 1 week and 2 weeks in mouse experimental group.
It is concluded that newly-developed inorganic bovine bone mineral(OCS-B) is a flourishing bone-forming material and biocompatible material.

Keywords: bovine bone, bone regeneration, calvarial defect

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