Journal List > J Korean Acad Periodontol > v.34(4) > 1049453

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Lee, Kwon, Park, Herr, Chung, and Kim: Osteopromotive effect of Titanium Reinforced-ePTFE membrane
Original Article

The Journal of the Korean Academy of Periodontology 2004; 34(4): 711-722.

Published online: 31 December 2004

DOI: https://doi.org/10.5051/jkape.2004.34.4.711

Osteopromotive effect of Titanium Reinforced-ePTFE membrane

Jean Lee1, Young-Hyuk Kwon1, Joon-Bong Park1, Yeek Herr1, Jong-Hyuk Chung1, Chong-Kwan Kim2

1Department of Periodontology, Kyung Hee University, Seoul, Korea.

2Department of Periodontology, Research Institute for Periodontal Regeneration College of Dentistry and Brain Korea 21 project of Medical Sciences, Yonsei University, Seoul, Korea.

Corresponding author (kyhyuk@khu.ac.kr)

Copyright © 2004 Korean Academy of Periodontology

Abstract

The purpose of this study is to evaluate the regenerated bone histollogically using titanium reinforced ePTFE(TR-ePTFE) membrane and to investigate cell occlusiveness, wound stabilization and tissue integration of TR-ePTFE membrane.
Adult male rabbits (mean BW 2kg) and TR9W (W.L.Gore&Associate.INC,USA) were used in this study.
Intramarrow penetration defects were surgically created with round carbide bur(HP long #6) on calvaria of rabbits. TR-ePTFE membrane was applied to defect. Then guided bone regeneration was carried out using TRePTFE membrane and resorbable suture. At 2,4,8,12 weeks after the surgery, animals were sacrificed. Nondecalcified specimens were processed for histologic analysis.
The result and conclusion of this study were as follows:
1. TR-ePTFE membrane had good ability of biocompatibility and cell occlusiveness.
2. space making for guided bone regenerayion was good at TR-ePTFE membrane.
3. Tissue integration was not good at TR-ePTFE membrane. So, wound stabilization was not good.
4. At 8 weeks, 12 weeks after GBR procedure, bone formation was seen.
From the above results, TR-ePTFE membrane fixed tightiy on alveolar bone might be recommended for the early bone formation.

Keywords: TR-ePTFE, cell occlusiveness, wound stabilization, tissue integration

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