Journal List > J Korean Acad Periodontol > v.34(2) > 1049425

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Lee, Park, Kwon, Herr, and Cho: Effect of Enamel Matrix Derivative on Guided Bone Regeneration with Intramarrow Penetration
Original Article

The Journal of the Korean Academy of Periodontology 2004; 34(2): 393-410.

Published online: 30 June 2004

DOI: https://doi.org/10.5051/jkape.2004.34.2.393

Effect of Enamel Matrix Derivative on Guided Bone Regeneration with Intramarrow Penetration

Young-Jong Lee1, Joon-Bong Park1, Young-Hyuk Kwon1, Yeek Herr1, Kyoo-Sung Cho2

1Department of Periodontology, Kyung Hee University, Seoul, Korea.

2Department of Periodontology, Colleage of Dentistry, Yonsei University, Seoul, Korea.

Corresponding author (jbpark@khu.ac.kr)

Copyright © 2004 Korean Academy of Periodontology

Abstract

The purpose of this study was to investigate effect of enamel matrix derivative on guided bone regeneration with intramarrow penetration in rabbits. Eight adult male rabbits (mean BW 2Kg) were used in this study. Intramarrow penetration defects were surgically created with round carbide bur(HP long #6) on calvaria of rabbits. Defects were assigned to the control group grafted with mixture of the same quantity of demineralized freeze-dried bone allograft and deproteinized bovine bone mineral. Then, guided bone regeneration was carried out using resorbable membrane and suture. Enamel matrix derivative applied to defects was assigned to the test group. And treated as same manners as the control group. At 1, 2, 3 and 8 weeks after the surgery, animals were sacrificed, specimens were obtained and stained with Hematoxylin-Eosin for light microscopic evaluation.
The results of this study were as follows:
1. At 1, 2 and 3 weeks, no differences were observed between the control group and the test group in the aspect of bone formation around bone graft.
2. Proliferation of blood capillary was faster in the test group than in the control group.
3. Bone regeneration in intramarrow penetration was faster in the test group than in the control group.
4. At 8 weeks, new osteoid tissue formation around bone graft was more prominent in the test group than in the control group.
From the above results, enamel matrix derivative might be considered as the osteopromotion material and effective in the guided bone regeneration with intramarrow penetration.

Keywords: mel Matrix Denvative, Guide Bone Regeneration

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