Journal List > J Korean Acad Periodontol > v.34(2) > 1049423

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Kim, Chung, Kim, and Kim: Expression of mRANKL in rat PDL cell
Original Article

The Journal of the Korean Academy of Periodontology 2004; 34(2): 367-375.

Published online: 30 June 2004

DOI: https://doi.org/10.5051/jkape.2004.34.2.367

Expression of mRANKL in rat PDL cell

Hyun-Soo Kim, Hyun-Ju Chung, Young Joon Kim, Ok-Su Kim

Department of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University, Korea.

Copyright © 2004 Korean Academy of Periodontology

Abstract

As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease.
This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1β in the concentration of 0.01~10 ng/ml.
The results are as follows;
1. Periodontal ligament cells which stimulated by IL-1β increased soluble RANKL synthesis by dose-dependent pattern in the concentration of 0.01~10 ng/ml.
2. IL-1β induced mRANKL expression in dose-dependent manner in the concentration of 0.01~5 ng/ml.
3. mOPG expression was not to be influenced by IL-1β.
These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.

Keywords: RANKL, OPG, periodontal ligament cell

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