Journal List > J Korean Acad Periodontol > v.33(4) > 1049384

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Kim, Hwang, Kim, Kim, Lee, Lee, Cho, Chai, Kim, and Choi: The effects of polylactic/polyglycolic copolymer (PLA/PGA) membrane on the healing of 1-wall intrabony defects in beagle dogs
Original Article

The Journal of the Korean Academy of Periodontology 2003; 33(4): 599-613.

Published online: 31 December 2003

DOI: https://doi.org/10.5051/jkape.2003.33.4.599

The effects of polylactic/polyglycolic copolymer (PLA/PGA) membrane on the healing of 1-wall intrabony defects in beagle dogs

Sung Koo Kim1, Sung Joon Hwang1, Min Kyoung Kim1, Chang Sung Kim1, Doug Youn Lee2, 3, Yong Keun Lee3, Kyoo Sung Cho1, 2, Jung Kiu Chai1, Chong Kwan Kim1, 2, Seong Ho Choi1, 2

1Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Korea.

2Brain Korea 21 Project for Medical Science, Korea.

3Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University, Korea.

Copyright © 2003 Korean Academy of Periodontology

Abstract

The goal of periodontal treatment is regeneration of the periodontium. Bone graft and absorbable PLA/PGA membrane have been used for this purpose. In this study, 4×4mm 1-wall intrabony defects were surgically created bilaterally in the mandible of five male beagles. The control group went through a conventional flap operation, while the experimental group I was treated with absorbable PLA/PGA membranes only, group II was treated with absorbable membrane and calcium phosphate.
The results are the following:
1. The defect height was 4.82±0.45mm in the control group, 4.93±0.79mm in the experimental I group, and 4.92±0.62mm in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05).
2. The amount of junctional epithelium migration was 30.90±9.92% of the defect height in the control group, 39.16±7.51% in the experimental I group, and 38.68±12.22% in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05).
3. The amount of connective tissue adhesion was 36.38±9.03% in the control group, 14.73±3.93% in experimental I group, and 27.87±9.70% experimental II group. Experimental group I was a statistically significantly different from control group(P<0.05).
4. The amount of new cementum regeneration was 32.92±10.51%, 50.04±7.61%, and 39.62±12.14% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05).
5. The amount of new alveolar bone regeneration was 27.24±7.49%, 40.75±8.03%, and 36.47±15.11% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05).
The results suggest that the use of PLA/PGA membrane in 1-wall intrabony defect of beagle dogs may promote periodontal regeneration. Further studies are required to determine their regeneration effects.

Keywords: PLA/PGA membrane, calcium phosphate, 1-wall defects, periodontal regeneration

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