The purpose of this study is to evaluate the biocompatibility and the bioresorbability of several types of calcium polyphosphate made through change of manufacturing process for 12 month. To solve limitation of calcium phosphate, we developed a new ceramic, Calcium Polyphosphate(CPP), and report the biologic response to CPP in extraction sites of beagle dog. Porous CPP blocks were prepared by condensation of anhydrous Ca(H₂PO₄)₂ to form non-crystalline Ca(PO₃)₂ and then milled to produce CPP powder. CPP powder, CPP block, and CPP granules added with Na₂O were implanted in extraction sockets and histologic observation were performed at 12 months later. Like 3 months results, histologic observation at 12 months revealed that CPP matrix were mingled with and directly apposed to new bone without any adverse tissue reaction. CPP powder show direct bony contact, but new bone formation and fibrous tissue encapsulation showed in CPP block. 10% Na₂O CPP granules show more inflammatory cells infiltration around graft materials compared at 3 month, but 15% Na₂O CPP granules show less. This result revealed that regardless of addition of Na₂O, CPP had a high affinity for bone and had been resorbed slowly.