Journal List > J Korean Acad Periodontol > v.29(3) > 1049094

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Wikesjo, Hanisch, Danesh-Meyer, Cho, and Kim: Tissue Engineering with rhBMP-2: Bone Reconstruction in Implant Dentistry
Review

The Journal of the Korean Academy of Periodontology 1999; 29(3): 447-468.

Published online: 30 September 1999

DOI: https://doi.org/10.5051/jkape.1999.29.3.447

Tissue Engineering with rhBMP-2: Bone Reconstruction in Implant Dentistry

Ulf ME Wikesjo*, Oliver Hanisch**, Michael J Danesh-Meyer***, Kyoo Sung Cho****, Chong Kwan Kim****

Professor and Vice Chairman

Assistant Professor

Assistant Clinical Professor

Professor

Professor

*Temple University School of Dentistry, Department of Periodontology Director, Postgraduate Specialty Program in Periodontology Director, Laboratory for Applied Periodontal and Craniofacial Regeneration Diplomate, American Board of Periodontology, USA.

**University of Aachen Medical Center, Department of Prosthodontics, Germany. Visiting Assistant Professor Temple University School of Dentistry, Department of Periodontology Research Fellow, Laboratory for Applied Periodontal, USA.

***Temple University School of Dentistry Department of Periodontology and Postgraduate Specialty Program in Periodontology Associate Scientist, Laboratory for Applied Periodontal and Craniofacial Regeneration, USA.

****Department of Periodontology, College of Dentistry, Research Institute for Periodontal Regeneration, Yonsei University, Seoul, Korea.

Copyright © 1999 Korean Academy of Periodontology

Abstract

The preclinical and clinical studies reviewed herein show that rhBMP-2 induces normal physiologic bone in relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone, and allows placement and osseointegration of dental implants. Clearly, the bone inducing capacity of rhBMP-2 is carrier and site dependent. rhBMP-2 in an absorbable collagen sponge carrier induces relevant bone formation in space providing defects. Space providing carries extends this possibility to non-space providing sites. Notably, some ceramic and polymeric biomaterials may substantially interfere with rhBMP-2 induced osteogenesis.

Keywords: Tissue Engineering, rhBMP-2, Bone Reconstruction, Implant Dentistry, absorbable collagen sponge, carrier

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