Journal List > J Korean Acad Periodontol > v.29(2) > 1049084

J Korean Acad Periodontol. 1999 Jun;29(2):325-332. Korean.
Published online June 30, 1999.
Copyright © 1999 Korean Academy of Periodontology
In Vitro Antibacterial Effect of a Mouthrinse Containing CPC (Cetylpyridinium Chloride), NaF and UDCA(ursodeoxycholic acid) against Major Periodontopathogens
Chong-Kwan Kim,1 Bong-Kyu Choi,2 Yun-Jung Yoo,2 Sang-Nyun Kim,3 Jae-Kyun Seok,3 and Moon-Moo Kim3
1Department of Periodontology, Research Institute for Periodontal Regeneration, Dental College, Yonsei University, Korea.
2Department of Oral Biology, Dental College, Yonsei University, Korea.
3LG Household and Health Care, R & D Institute, Korea.

The antibacterial efficacy of a mouthrinse(Denta Gargle) containing CPC(cetylpyridinium chloride), NaF and UDCA(ursodeoxycholic acid), on major periodontopathogens, was in vitro examined and compared with that of Listerine by a broth dilution method. The bacteria tested were Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Fusobacterium nucleatum subsp. vincentii, Prevotella intermedia, Porphyromonas gingivalis and Treponema denticola. The growth of all the bacteria were completely inhibited by a 1-min exposure to the both mouthrinses. When diluted at 1:5 or more, all bacteria analyzed but P. intermedia were not inhibited by Listerine. In contrast, Denta Gargle showed highly increased maximum inhibitory dilutions(MID) against all periodontopathogens included in this study, with MIDs ranging from 5-fold(F. nucleatum) to 160-fold dilutions(P. intermedia). The MIDs against A. actinomycetemcomitans, B. forsythus, P. gingivalis and T. denticola. were 1:40, 1:80, 1:80 and 1:80, respectively.

Keywords: Mouthrinse; Cetylpyridinium chloride; Periodontopathogens; Maximum inhibitory dilutions(MID)