This study was undertake to assess the effect of 30% minocycline containing polycaprolactone strip to adult periodontitis patient with respect to utility as a monotherapy, effectiveness of this drug device compared to scaling and root planning, and their ability to enhance scaling and root planning. 48 teeth of 12 adult patients who had at least one teeth qualifying pocket≥4mm at each quadrant were enrolled in this study by split mouth design. All patients received supragingival scaling and oral hygiene instruction 2 weeks prior to the study. At baseline(time 0), enrolled tooth at each quadrant randomly assigned following one of 4 treatment modalities: root planing only(RP); root planing and placement of minocycline strip into pocket for a week(RP+MC); placement of minocycline strip into pocket for a week with out root planing(MC); 2 consecutive placement of minocycline strip into pocket for 2 weeks by one week(MCx2). Each teeth was evaluated at baseline and months 1, 3 and 6. Clinical indices included plaque index, bleeding on probing, probing pocket depth and clinical attachment level. Among 4 groups, RP+MC group showed the lowest percent site of bleeding on probing at 1, 3 and 6 months. Compared to baseline, all group showed significant reduction of pocket depth at 1, 3 and 6 months. The average pocket depth reduction in RP+MC sites was significantly greater than in the sites receiving RP, MC, and MCx2 at 3 months and in sites receiving MC and MCx2 at 6 months. The reduction in clinical attachment at the sites receiving RP+MC was significantly greater than in the sites receiving RP, MC, and MCx2 at 3 months. Between MC and MCx2 groups, no statistically significances was shown in reduction of pocket depth and clinical attachment level at all period examined. This result suggest that the use of 30% minocycline containing strip may improve periodontal health and may be an effective adjunct to conventional nonsurgical therapy in the treatment of adult periodontitis.