Journal List > J Korean Acad Periodontol > v.27(3) > 1048963

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Park, Herr, Kwon, Bae, and Chung: Effects of Ethanolic Extracts of Scutellaria Radix on the alveolar bone formation in the extract socket of rat
Original Article

The Journal of the Korean Academy of Periodontology 1997; 27(3): 443-457.

Published online: 30 September 1997

DOI: https://doi.org/10.5051/jkape.1997.27.3.443

Effects of Ethanolic Extracts of Scutellaria Radix on the alveolar bone formation in the extract socket of rat

Joon Bong Park1, Yeek Herr1, Young Hyuk Kwon1, Ki Hwan Bae2, Chong Pyung Chung3

1College of Dentistry, KyungHee University, Korea.

2College of Pharmacology, ChoongNam National University, Korea.

3College of Dentistry, Seoul National University, Korea.

Copyright © 1997 Korean Academy of Periodontology

Abstract

The purpose of this study was to evaluate the effects of ethanolic extracts of Scutellaria Radix on the alveolar bone formation in the extract socket of rat. Thirty-six Sprague-dawley rats were used in this study. Mean body weight of rat was 130±5g.
Experimental animal were administered 0.4% β-aminopropionitril(Sigma, USA) with the solid commercial food for 5 days. All the maxillary 1st molar of the rats were extracted by using of the tissue forcep under the general anesthesia with Pentobarbital sodium(Tokyo Chemical Co., Japan) injection into intraperitoneal space.
All the extracted rats were divided into two group, experimental group which were feeded the solid food mixed ethanolic extracts of Scutellaria Radix, and control group which were feeded same food without reagent.
At 1, 3, 5, 7, 9 and 14th days after tooth extraction, rats in both groups were serially sacrificed respectively. All the specimen were treated as usual method and prepared Hematoxylin-eosin stain for the light microscopic observation.
The results were as follows :

  1. Bone formation of extracted socket starts from the area on remained periodontal ligament than other area.

  2. In the case of administration of the extracted Scutellaria Radix showed rapid healing process of connective tissue than non-administrated group.

  3. In the case of administration of the extracted Scutellaria Radixshowed rapid osteogenesis than non-administrated

With above results, it was concluded that ethanolic extracts of Scutellaria Radix may play a favorable role on the healing process of exatraction socket after extraction in rats. It was suggested that further study to evaluate the different concentration and administration method of ethanolic extracts of the Scutellaria Radix into same experimental model.

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