Pathophysiology of Osteolysis

Ick-Hwan Yang

doi:10.5371/jkhs.2011.23.1.1

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Yang: Pathophysiology of Osteolysis

Review Article

The Journal of the Korean Hip Society

The Journal of the Korean Hip Society 2011; 23(1): 1-6.

Published online: 31 March 2011

DOI: https://doi.org/10.5371/jkhs.2011.23.1.1

Pathophysiology of Osteolysis

Ick-Hwan Yang, MD

Department of Orthopaedic Surgery, College of Medicine, Yonsei University, Seoul, Korea.

Address reprint request to Ick-Hwan Yang, MD. Department of Orthopaedic Surgery, Gangnam Severance Hospital, College of Medicine, Yonsei University, 146-92 Dogok-dong, Gangnam-gu, Seoul 135-720, Korea. TEL: +82-2-2019-3416, FAX: +82-2-573-5393, ihyang@yuhs.ac

Received 1 July 2010 Revised 10 January 2011 Accepted 11 January 2011

Abstract

Total joint replacement has been successful and cost-effective for restoring function and mobility to patients since its advent more than thirty years ago. With the improvements in prophylaxis against infection and the fatigue strength of the components, skeletal fixation, wear and its sequelae have become the primary limitations for the longevity of joint replacement. Initially termed "cement disease," osteolysis is believed to be a biological response not only to polymethylmethacrylate, but also to a variety of particles that may originate at several locations around a joint replacement. Recent research has been directed at understanding the biological cascade of events that is initiated by particulate debris and that results in periprosthetic bone loss.

Keywords: Total hip arthroplasty, Wear, Osteolysis, Pathophysiology

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