Journal List > J Korean Hip Soc > v.20(4) > 1048593

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Chung, Lee, Kim, Bae, and Park: The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis
Original Article

The Journal of the Korean Hip Society 2008; 20(4): 320-325.

Published online: 3 May 2016

DOI: https://doi.org/10.5371/jkhs.2008.20.4.320

The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis

Whan Young Chung, Woo Suk Lee, Sang Bum Kim, In Tak Bae, Won Ki Park

Department of Orthopaedic Surgery, Konyang University College of Medicine, Daejeon, Korea.

wsleeos@kyuh.co.kr

Copyright © by Korean Hip Society

Abstract

Purpose

The aim of this study was to evaluate the expression of type II collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN).

Materials and Methods

We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type II collagen, aggrecan, VEGF-A and PEDF.

Results

The chondrocytes of the AVN group showed decreased expressions of type II collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05).

Conclusion

The cartilage matrix's formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.

Keywords: Avacular necrosis, Chondrocytes, Type II collagen, Aggrecan, VEGF-A, PEDF

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