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Chung, Bang, Lee, Lee, and Lee: Correlation of Natural Killer(NK) Cell Activity,Antibody Dependent Cellular Cytotoxicity(ADCC), and Serum Zinc Level in Behçet's Disease
Original Article

Annals of Dermatology 1994; 6(2): 152-156.

Published online: 28 November 2016

DOI: https://doi.org/10.5021/ad.1994.6.2.152

Correlation of Natural Killer(NK) Cell Activity,Antibody Dependent Cellular Cytotoxicity(ADCC), and Serum Zinc Level in Behçet's Disease

Kee-Yang Chung, Dongsik Bang, Seung Hun Lee, Eun So Lee, Sungnack Lee

Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

Background

Zinc which is widely used to treat Behcet's disease, is known to be an important modulator in various aspects of immunity including cell mediated immunity (CMI). CMI is suspected of playing a major role in the pathogenesis of Behçet's disease.

Objective

This study was done to clarify the relationship of CMI and zinc in Behçet's disease.

Methods

Serum zinc level, NK cell activity, and ADCC were measured in 83 patients with Behçet's diseade. The results were analyzed using multiple regression analysis.

Results

ADCC and serum zinc level were found to be two significant variables that affect NK cell activity positively and negatively, respectively.

Conclusion

Serum zinc is presumed to exert inhibitory effect on NK cell activity but does not affect ADCC in Behçet's disease patients.

Keywords: Behçet's disease, NK cell activity, ADCC, Serum zinc

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