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Park, Kim, Hann, Cho, and Koo: Studies on the Effects of Various Topical Phototoxic Drugs and UVA on Melanocytes of C57 BL Mice
Original Article

Annals of Dermatology 1991; 3(1): 15-22.

Published online: 28 November 2016

DOI: https://doi.org/10.5021/ad.1991.3.1.15

Studies on the Effects of Various Topical Phototoxic Drugs and UVA on Melanocytes of C57 BL Mice

Yoon Kee Park, You Chan Kim, Seung Kyung Hann, Moo Yon Cho, Sang Wahn Koo

Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

One hundred sixteen C57 BL mice were painted with either 8-MOP, 5-MOP or TMP solution in concentrations of 0.02%, 0.1%, and 0.5% each and UVA irradiated. Skin biopsies were performed at 1, 3, 5 and 7 weeks after LJVA irradiation.
The results measuring the number, area, and perimeter of the melanocytes after topical PLJVA were higher in the TMP-painted group than in the 8-MOP or 5-MOP painted groups. In all groups, the weekly changes showed an increasing value through five weeks. In comparing the drug concentrations used, 0.1% of chemicals produced the same or higher values than 0.5%.
There have been few studies on the effects of 5-MOP in photochemotherapy. In tho study 5-MOP produced a pigment-producing effect similar to 8-MOP. Therefore, if topical PIJVA with 5-MOP is used in clinical practice, we could expect a significant therapeutic effect in vitiligo.

Keywords: Melanocytes, 8-MOP, 5-MOP, TMP, Topical PUVA

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