Cytophagic histiocytic panniculitis(CHP) is a histiocytic disorder that was first described by Winkelmann and Crotty in 1980. We have recently experienced a case of CHP is a 21-year-old female who had developed recurrent fever and erythematous tender subcutaneous nodules, progressing to liver dysfunction and hemorrhagic diathesis. Histopathologically, infiltrates of large cytophagic histiocytes lacking atypia were present in the subcutis. Hemophagocytic histiocytes were observed in the bone marrow. Immunohistochemical studies were performed, and revealed positive immunoreactivity for lysozyme and T cell marker in the subcutaneous inflammatory lesions.