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Lee, Rhe, Houh, Oh, Kim, and Houh: A Pemphigus Vulgaris with IgG1 and IgG4 Subclass Autoantibodies
Case Report

Annals of Dermatology 1990; 2(1): 35-38.

Published online: 28 November 2016

DOI: https://doi.org/10.5021/ad.1990.2.1.35

A Pemphigus Vulgaris with IgG1 and IgG4 Subclass Autoantibodies

Suk Woo Lee, Jeong Ki Rhe, Dong Houh, Young Jin Oh, Young Whan Kim, Won Houh

Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

The distribution of pemphigus subclass autoantibodies in a patient with pemphigus vulgaris (PV) has been investigated by semiquantitative indirect immunofluorescence (IIF), using the HP series monoclonal antibodies specific for four human IgG subclasses on human foreskins. IgG1 and IgG4 intercellular substance-specific autoantibodies were detected in the serum of the patient, whereas IgG2 and IgG3 autoantibodies were absent.
In addition to foreskins, human tonsillar epithelia were used as substrates of IIF for detecting the PV autoantibodies and it was one of satisfactory substitutes for monkey esophagus.

Keywords: Human tonsillar epithelium, Monoclonal antibodies specific for human IgG subclasses, Pemphigus subclass autoantibodies

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