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Jeong, Lee, Bak, Oh, Jung, Chang, and Choi: Detection of Human Papilloma Virus DNA in Seborrheic Keratosis of Korean Skin
Original Article

Annals of Dermatology 2007; 19(3): 99-105.

Published online: 30 September 2007

DOI: https://doi.org/10.5021/ad.2007.19.3.99

Detection of Human Papilloma Virus DNA in Seborrheic Keratosis of Korean Skin

Young Il Jeong, M.D., Woo Jin Lee, M.D., Hana Bak, M.D., Sang Hyun Oh, M.D., Hae Jin Jung, M.D.*, Sung Eun Chang, M.D., Jee Ho Choi, M.D.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

*Research Institute of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Corresponding author (cse@amc.seoul.kr)

Copyright © 2007 The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

Background

DNA of epidermodysplasia verruciformis(EV)-associated human papillomaviruses (HPVs) has been detected in benign and malignant skin tumors and other proliferative diseases of epithelial origin. The objective of this study was to determine the association of EV-associated HPV DNA in nongenital seborrheic keratoses(SK) in Korean patients.

Subjects and Methods

Forty biopsy specimens were collected from patients with nongenital SK and cutaneous SCC and controls. All tissue samples were examined by PCR.

Results

By polymerase chain reaction(PCR), EV-associated HPV DNA was detected in 15 of 40 nongenital SK(37.5%) compared with 1 of 40 cutaneous squamous cell carcinomas(SCC) samples and 3 of 40 healthy controls. Detected viruses in SK included HPV 20(n=6), HPV 23 (n=2). The rest tested positive for HPV 5, 16, 17, 22, 25, 37, and RTRX4.

Conclusion

Our findings suggest that EV-associated HPV may be involved in the pathogenesis of nongenital SK of Asian skin.

Keywords: Human papillomavirus, Seborrheic keratosis

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