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Seo, Cho, Cho, Jung, Ro, Kim, and Hong: Effect of Trans-4-Aminomethylcyclohexanecarboxylic Acid on the Proliferation and Melanization in Cultured Normal Human Melanocytes
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Annals of Dermatology 2007; 19(2): 60-67.

Published online: 30 June 2007

DOI: https://doi.org/10.5021/ad.2007.19.2.60

Effect of Trans-4-Aminomethylcyclohexanecarboxylic Acid on the Proliferation and Melanization in Cultured Normal Human Melanocytes

Seong Jun Seo, M.D.1, Sung Hyun Cho, M.D.1, Wan Ik Cho, M.D.1, Mi Sook Jung, M.D.2, Sung Wook Ro, M.D.3, Myeung Nam Kim, M.D.1, Chang Kwun Hong, M.D.2

1Department of Dermatology, College of Medicine Chung-Ang University, Seoul, Korea.

2College of Medicine Chung-Ang University, Institute, Seoul, Korea.

3Gowoonsesang Dermatologic Clinic, Seoul, Korea.

Corresponding author (ckhong@cum.ac.kr)

Copyright © 2007 The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

Background

Trans-4-aminomethylcyclohexanecarboxylic acid (tranexamic acid) has recently been reported to inhibit prostaglandin synthesis and hinder the pigmentation caused after UV radiation.

Objective

we evaluated the influence of tranexamic acid on the viability, morphogenesis and melanization of cultured normal human melanocytes.

Method

The cultured melanocytes from neonatal foreskin were exposed to UVB 20mJ/cm2, then treated with tranexamic acid [0.05microgram/ml, 0.05microgram/ml, and 0.5microgram/ml]. After 24 hours, the viability of melanocytes and the melanin concentration was measured. The number and length of the melanocytes' dendrites, and the expression level of tyrosinase, TRP-1 and TRP-2 were also evaluated.

Results

The viability of the melanocytes was decreased by tranexamic acid in a dose dependent manner (p<0.05). The increased melanin synthesis by UVB irradiation was decreased by tranexamic acid in a dose dependent manner (p<0.05). Also, the increased expressions of TRP-1, TRP-2 and tyrosinase after exposure to UV were statistically decreased by tranexamic acid in a dose dependent manner (p<0.05).

Conclusion

tranexamic acid may prevents UVB induced pigmentation.

Keywords: Melanocytes, Tranexamic acid, UVB

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