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Lee, You, Park, Yun, and Kim: Invasive Squamous Cell Carcinoma of the Oral Mucosa Associated with HPV Type 53
Case Report

Annals of Dermatology 2007; 19(1): 19-21.

Published online: 31 March 2007

DOI: https://doi.org/10.5021/ad.2007.19.1.19

Invasive Squamous Cell Carcinoma of the Oral Mucosa Associated with HPV Type 53

Seung Yoon Lee, M.D.1, Chung Eui You, M.D.1, Mi Youn Park, M.D.1, Hae Sun Yun, Ph.D.2, Sung Soon Kim, Ph.D.2

1Department of Dermatology, National Medical Center, Seoul, Republic of Korea.

2Center for AIDS Research, National Institute of Health, Korea Center for Disease Control and Prevention, Seoul, Korea.

Corresponding author (nmcderma@hanmail.net)

Copyright © 2007 The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

A 77-year old man presented with a fungating mass on the oral mucosa and lip, which had an irregular margin. An incisional biopsy of the mass revealed an invasive squamous cell carcinoma. PCR analysis detected HPV DNA in the biopsy specimen. The HPV type was determined as HPV-53 by direct cycle sequencing. This is the first report of HPV-53 in an oral malignant tumor.

Keywords: HPV-associated cancer, HPV type 53, Invasive squamous cell carcinoma, Oral cancer, Oral squamous cell carcinoma

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