Cutaneous gnathostomiasis has also been called larva migrans profundus and nodular migratory eosinophilic panniculitis. Human gnathostomiasis is caused mainly by the nematode Gnathostoma spinigerum. It causes migratory cutaneous, erythematous, indurated plaques and serious visceral sequelae. Medical treatment with mebendazole, albendazole, and ivermectin has been disappointing. Surgical excision of the parasite is the treatment of choice when possible.