Journal List > Ann Dermatol > v.14(1) > 1044781

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Park, Kim, Ryoo, Kim, and Lee: Chronic Hydroxyurea-induced Dermatomyositis-like Eruption Showing Epidermal Dysmaturation
Case Report

Annals of Dermatology 2002; 14(1): 28-30.

Published online: 15 March 2016

DOI: https://doi.org/10.5021/ad.2002.14.1.28

Chronic Hydroxyurea-induced Dermatomyositis-like Eruption Showing Epidermal Dysmaturation

Jae Hong Park, Chang Duk Kim, Young Wook Ryoo, Byung Chun Kim, Kyu Suk Lee

Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

Hydroxyurea is an effective treatment for a variety of myeloproliferative disodrers. A distinct cutaneous reaction to long-term administration of hydroxyurea has been characterized and designated hydroxyurea dermopathy. Epidermal dysmaturation refers to histologic changes that may be observed in the epidermis after any significant cytoreductive therapy.
We report a patient with hydroxyurea-induced dermatomyositis-like eruption showing epidermal dysmaturation who developed an erythematous scaly patches on the dorsal aspects of the hands while on long-term administration of hydroxyurea for chronic myelogenous leukemia.

Keywords: Hydroxyurea, Epidermal dysmaturation, Dermatomyositis

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