Diffuse plane xanthoma characteristically presents with asymptomatic, yellow-orange plaques that usually involve periorbital areas, neck, upper trunk and flexural folds. Al-though most cases of diffuse plane xanthoma are associated with multiple myeloma, several cases have been described with different lymphoproliferative disorders and other miscellaneous diseases. We report herein two cases of diffuse plane xanthoma which are not associated with underlying disease.