Hypertrichosis has been frequently observed during the oral administration of the potent antihypertensive agent, minoxidil. However, hypertrichosis is uncommon after treatment with topical minoxidil for alopecia, and usually occurs in areas close to the site of the application. We describe a 52-year-old woman with diffuse facial hypertrichosis. She developed abnormal hypertrichosis while applying the optimal dose of 3% topical minoxidil for 2 months for the treatment of androgenetic alopecia.