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Abstract
Angiocentric T-cell lymphomas have been described as a distinctive clinicopathologic entity in the spectrum of peripheral T-cell lymphomas, with a prominent invasion of blood vessels by lymphomatous cells. In these conditions, the presence of Epstein-Barr virus (EBV) genomes has been demonstrated, suggesting that EBV might play a major role in their cause.
Herein, we report a case of cutaneous angiocentric T cell lymphoma associated with the EBV. The patient was diagnosed with nasal angiocentric T cell lymphoma 5 months ago, and treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) combination chemotherapy. After three cycles of CHOP, skin lesions developed. A skin biopsy specimen showed an angiocentric and angioinvasive infiltrate containing some atypical lymphocytes. EBV encoded RNA (EBER) was demonstrated in lesional skin by in situ hybridization.
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