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Lim, Kim, Ro, and Chang: Adverse Reaction to Methotrexate and Etretinate in a Patient with Psoriasis
Case Report

Annals of Dermatology 1989; 1(1): 59-63.

Published online: 28 November 2016

DOI: https://doi.org/10.5021/ad.1989.1.1.59

Adverse Reaction to Methotrexate and Etretinate in a Patient with Psoriasis

Ee Seok Lim, Myeung Nam Kim, Byung In Ro, Chin Yo Chang

Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology

Abstract

A 49-year-old Caucasian male patient suffered from fever general weakness and diffuse hair loss on the scalp for 3 days. Skin lesions showed erythematous scaly patches with pustules and erosions on the lower extremities and perianal region, and multiple ulcerations on the labial mucoas. A complete blood cell count revealed thrombocytopenia and leukopenia, which gradually worsened day after day (platelet: 29, 000/mm2, WBC: 1,000/mm3). Candida albicans was isolated from the lesions of the oral cavity and lower extremities.
Twelve days prior to the visit, he had taken etretinate Tegison®) P.O.25mg/day, prednisolone P.O. 50mg1dy and methotrexate P.O. 15mg/day for 5 days for the treatment of psoriasis.
We presume that these adverse reactions may be synergistic adverse reactions, probably due to methotrexate and etretinate in consideration of the patient's history.

Keywords: Adverse reaction, Etretinate, Methotrexate, Psoriasis

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