Quality of Life in Colorectal Cancer Patients with Chemotherapy-Induced Peripheral Neuropathy

Jeong Hye Kim; Kyung Sook Choi; Tae Won Kim; Yong Sang Hong

doi:10.5388/jkon.2011.11.3.254

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Kim, Choi, Kim, and Hong: Quality of Life in Colorectal Cancer Patients with Chemotherapy-Induced Peripheral Neuropathy

Original Article

Journal of Korean Oncology Nursing

Journal of Korean Oncology Nursing 2011; 11(3): 254-262.

Published online: 30 November 2011

DOI: https://doi.org/10.5388/jkon.2011.11.3.254

Quality of Life in Colorectal Cancer Patients with Chemotherapy-Induced Peripheral Neuropathy

Jeong Hye Kim¹, Kyung Sook Choi², Tae Won Kim³, Yong Sang Hong⁴

¹Clinical Nurse Specialist, Asan Medical Center, Seoul, Korea.

²Professor, Department of Nursing, Chung-Ang University, Seoul, Korea.

³Professor, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

⁴Assistant Professor, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Address reprint requests to: Choi, Kyung Sook. Department of Nursing, Chung-Ang University, 211 Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea. Tel: +82-2-820-5677, Fax: +82-2-824-7961, kschoi@cau.ac.kr

Received 1 October 2011 Accepted 2 November 2011

Abstract

Purpose

The purpose of this study was to identify the quality of life in colorectal cancer patients with chemotherapy-induced peripheral neuropathy.

Methods

A total of 93 patients were recruited in the cross-sectional survey design. Quality of life in colorectal cancer patients were measured by European Organization for Research and Treatment of Cancer (EORTC) QLQ C30 and CIPN20.

Results

In the QLQ C30, the mean score of the global health status was 59.41, the functional scale was 73.29 and symptom scale was 26.72. In CIPN20, the mean score of sensory scale was 32.70, autonomic scale was 22.88 and motor scale was 16.12. In the QLQ C30, the global health status showed significant differences according to surgery (p=.027) and the functional scale, and the symptom scale showed significant differences according to gender (p=.046, p=.020) and nonpharmacologic intervention (p=.001, p=.009). The CIPN20, the sensory scale showed significant differences according to age (p=.006), DM (p=.005), grade of CIPN (p=<.001) the status of chemotherapy (p=.001) and nonpharmacologic intervention (p=.010).

Conclusion

The level of quality of life in colorectal cancer patients with peripheral neuropathy was relatively low. There is a need for developing a nursing intervention for colorectal cancer patients to improve their quality of life and to decrease chemotherapy-induced peripheral neuropathy.

Keywords: Chemotherapy, Peripheral Neuropathy, Quality of Life, Colorectal Cancer

Figures and Tables

Table 1

General and Clinical Characteristics of patients (N=93)

ECOG PS, Eastern Cooperative Oncology Group performance status; CIPN20, Chemotherapy induced peripheral neuropathy20; DM, Diabetes Mellitus.

Table 2

EORTC QLQ C30 and CIPN 20 (N=93)

QLQ C30, Quality of life questionnaire Core 30; CIPN20, Chemotherapy induced peripheral neuropathy20.

Table 3

Differences of QLQ C30 and CIPN 20 according to General and Clinical characteristics (N=93)

QLQ C30, Quality of life questionnaire Core 30; CIPN20, Chemotherapy induced peripheral neuropathy20; DM, Diabetes Mellitus.

Table 4

Correlation between QLQ C30 and CIPN 20 (N=93)

QLQ C30, Quality of life questionnaire Core 30; CIPN20, Chemotherapy induced peripheral neuropathy20.

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